Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome zeta chain)
1_MFLTR 6_ SEYDR 11_ GVNTF 16_ SPEGR 21_ LFQVE 26_ YAIEA 31_ IKLGS 36_ TAIGI 41_ QTSEG 46_ VCLAV 51_ EKRIT 56_ SPLME 61_ PSSIE 66_ KIVEI 71_ DAHIG 76_ CAMSG 81_ LIADA 86_ KTLID 91_ KARVE 96_ TQNHW 101_ FTYNE 106_ TMTVE 111_ SVTQA 116_ VSNLA 121_ LQFGE 126_ EDADP 131_ GAMSR 136_ PFGVA 141_ LLFGG 146_ VDEKG 151_ PQLFH 156_ MDPSG 161_ TFVQC 166_ DARAI 171_ GSASE 176_ GAQSS 181_ LQEVY 186_ HKSMT 191_ LKEAI 196_ KSSLI 201_ ILKQV 206_ MEEKL 211_ NATNI 216_ ELATV 221_ QPGQN 226_ FHMFT 231_ KEELE 236_EVIKD
1: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)