HLA class II histocompatibility antigen, DM alpha chain (MHC class II antigen DMA) (Really interesting new gene 6 protein)
1_MGHEQ 6_ NQGAA 11_ LLQML 16_ PLLWL 21_ LPHSW 26_ AVPEA 31_ PTPMW 36_ PDDLQ 41_ NHTFL 46_ HTVYC 51_ QDGSP 56_ SVGLS 61_ EAYDE 66_ DQLFF 71_ FDFSQ 76_ NTRVP 81_ RLPEF 86_ ADWAQ 91_ EQGDA 96_ PAILF 101_ DKEFC 106_ EWMIQ 111_ QIGPK 116_ LDGKI 121_ PVSRG 126_ FPIAE 131_ VFTLK 136_ PLEFG 141_ KPNTL 146_ VCFVS 151_ NLFPP 156_ MLTVN 161_ WHDHS 166_ VPVEG 171_ FGPTF 176_ VSAVD 181_ GLSFQ 186_ AFSYL 191_ NFTPE 196_ PSDIF 201_ SCIVT 206_ HEIDR 211_ YTAIA 216_ YWVPR 221_ NALPS 226_ DLLEN 231_ VLCGV 236_ AFGLG 241_ VLGII 246_ VGIVL 251_ IIYFR 256_KPCSG
1: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO