HLA class II histocompatibility antigen, DM beta chain (MHC class II antigen DMB) (Really interesting new gene 7 protein)
1_MITFL 6_ PLLLG 11_ LSLGC 16_ TGAGG 21_ FVAHV 26_ ESTCL 31_ LDDAG 36_ TPKDF 41_ TYCIS 46_ FNKDL 51_ LTCWD 56_ PEENK 61_ MAPCE 66_ FGVLN 71_ SLANV 76_ LSQHL 81_ NQKDT 86_ LMQRL 91_ RNGLQ 96_ NCATH 101_ TQPFW 106_ GSLTN 111_ RTRPP 116_ SVQVA 121_ KTTPF 126_ NTREP 131_ VMLAC 136_ YVWGF 141_ YPAEV 146_ TITWR 151_ KNGKL 156_ VMPHS 161_ SAHKT 166_ AQPNG 171_ DWTYQ 176_ TLSHL 181_ ALTPS 186_ YGDTY 191_ TCVVE 196_ HTGAP 201_ EPILR 206_ DWTPG 211_ LSPMQ 216_ TLKVS 221_ VSAVT 226_ LGLGL 231_ IIFSL 236_ GVISW 241_ RRAGH 246_ SSYTP 251_ LPGSN 256_YSEGW
1: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO