Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)
1_MEAFL 6_ GSRSG 11_ LWAGG 16_ PAPGQ 21_ FYRIP 26_ STPDS 31_ FMDPA 36_ SALYR 41_ GPITR 46_ TQNPM 51_ VTGTS 56_ VLGVK 61_ FEGGV 66_ VIAAD 71_ MLGSY 76_ GSLAR 81_ FRNIS 86_ RIMRV 91_ NNSTM 96_ LGASG 101_ DYADF 106_ QYLKQ 111_ VLGQM 116_ VIDEE 121_ LLGDG 126_ HSYSP 131_ RAIHS 136_ WLTRA 141_ MYSRR 146_ SKMNP 151_ LWNTM 156_ VIGGY 161_ ADGES 166_ FLGYV 171_ DMLGV 176_ AYEAP 181_ SLATG 186_ YGAYL 191_ AQPLL 196_ REVLE 201_ KQPVL 206_ SQTEA 211_ RDLVE 216_ RCMRV 221_ LYYRD 226_ ARSYN 231_ RFQIA 236_ TVTEK 241_ GVEIE 246_ GPLST 251_ ETNWD 256_IAHMI
1: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1