Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome delta chain) (Proteasome subunit Y)
1_MAATL 6_ LAARG 11_ AGPAP 16_ AWGPE 21_ AFTPD 26_ WESRE 31_ VSTGT 36_ TIMAV 41_ QFDGG 46_ VVLGA 51_ DSRTT 56_ TGSYI 61_ ANRVT 66_ DKLTP 71_ IHDRI 76_ FCCRS 81_ GSAAD 86_ TQAVA 91_ DAVTY 96_ QLGFH 101_ SIELN 106_ EPPLV 111_ HTAAS 116_ LFKEM 121_ CYRYR 126_ EDLMA 131_ GIIIA 136_ GWDPQ 141_ EGGQV 146_ YSVPM 151_ GGMMV 156_ RQSFA 161_ IGGSG 166_ SSYIY 171_ GYVDA 176_ TYREG 181_ MTKEE 186_ CLQFT 191_ ANALA 196_ LAMER 201_ DGSSG 206_ GVIRL 211_ AAIAE 216_ SGVER 221_ QVLLG 226_ DQIPK 231_FAVAT
1: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues