5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin 1D alpha receptor) (5-HT-1D-alpha) (Serotonin receptor 1D)
1_MSPLN 6_ QSAEG 11_ LPQEA 16_ SNRSL 21_ NATET 26_ SEAWD 31_ PRTLQ 36_ ALKIS 41_ LAVVL 46_ SVITL 51_ ATVLS 56_ NAFVL 61_ TTILL 66_ TRKLH 71_ TPANY 76_ LIGSL 81_ ATTDL 86_ LVSIL 91_ VMPIS 96_ IAYTI 101_ THTWN 106_ FGQIL 111_ CDIWL 116_ SSDIT 121_ CCTAS 126_ ILHLC 131_ VIALD 136_ RYWAI 141_ TDALE 146_ YSKRR 151_ TAGHA 156_ ATMIA 161_ IVWAI 166_ SICIS 171_ IPPLF 176_ WRQAK 181_ AQEEM 186_ SDCLV 191_ NTSQI 196_ SYTIY 201_ STCGA 206_ FYIPS 211_ VLLII 216_ LYGRI 221_ YRAAR 226_ NRILN 231_ PPSLY 236_ GKRFT 241_ TAHLI 246_ TGSAG 251_ SSLCS 256_ LNSSL 261_ HEGHS 266_ HSAGS 271_ PLFFN 276_ HVKIK 281_ LADSA 286_ LERKR 291_ ISAAR 296_ ERKAT 301_ KILGI 306_ ILGAF 311_ IICWL 316_ PFFVV 321_ SLVLP 326_ ICRDS 331_ CWIHP 336_ ALFDF 341_ FTWLG 346_ YLNSL 351_ INPII 356_ YTVFN 361_ EEFRQ 366_ AFQKI 371_VPFRK
1: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:33762731). Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity (PubMed:18476671, PubMed:20945968). May also play a role in regulating the release of other neurotransmitters (PubMed:18476671, PubMed:20945968). May play a role in vasoconstriction (PubMed:18476671, PubMed:20945968)