5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A)
1_MDILC 6_ EENTS 11_ LSSTT 16_ NSLMQ 21_ LNDDT 26_ RLYSN 31_ DFNSG 36_ EANTS 41_ DAFNW 46_ TVDSE 51_ NRTNL 56_ SCEGC 61_ LSPSC 66_ LSLLH 71_ LQEKN 76_ WSALL 81_ TAVVI 86_ ILTIA 91_ GNILV 96_ IMAVS 101_ LEKKL 106_ QNATN 111_ YFLMS 116_ LAIAD 121_ MLLGF 126_ LVMPV 131_ SMLTI 136_ LYGYR 141_ WPLPS 146_ KLCAV 151_ WIYLD 156_ VLFST 161_ ASIMH 166_ LCAIS 171_ LDRYV 176_ AIQNP 181_ IHHSR 186_ FNSRT 191_ KAFLK 196_ IIAVW 201_ TISVG 206_ ISMPI 211_ PVFGL 216_ QDDSK 221_ VFKEG 226_ SCLLA 231_ DDNFV 236_ LIGSF 241_ VSFFI 246_ PLTIM 251_ VITYF 256_ LTIKS 261_ LQKEA 266_ TLCVS 271_ DLGTR 276_ AKLAS 281_ FSFLP 286_ QSSLS 291_ SEKLF 296_ QRSIH 301_ REPGS 306_ YTGRR 311_ TMQSI 316_ SNEQK 321_ ACKVL 326_ GIVFF 331_ LFVVM 336_ WCPFF 341_ ITNIM 346_ AVICK 351_ ESCNE 356_ DVIGA 361_ LLNVF 366_ VWIGY 371_ LSSAV 376_ NPLVY 381_ TLFNK 386_ TYRSA 391_ FSRYI 396_ QCQYK 401_ ENKKP 406_ LQLIL 411_ VNTIP 416_ ALAYK 421_ SSQLQ 426_ MGQKK 431_ NSKQD 436_ AKTTD 441_ NDCSM 446_ VALGK 451_ QHSEE 456_ ASKDN 461_ SDGVN 466_EKVSC
1: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895, PubMed:21645528, PubMed:22300836, PubMed:35084960, PubMed:38552625). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538, PubMed:35084960). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:28129538, PubMed:35084960). HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (PubMed:18703043, PubMed:28129538, PubMed:35084960). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538, PubMed:35084960). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity)
2: (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV