ATP-binding cassette sub-family D member 3 (EC 3.1.2.-) (EC 7.6.2.-) (70 kDa peroxisomal membrane protein) (PMP70)
1_MAAFS 6_ KYLTA 11_ RNSSL 16_ AGAAF 21_ LLLCL 26_ LHKRR 31_ RALGL 36_ HGKKS 41_ GKPPL 46_ QNNEK 51_ EGKKE 56_ RAVVD 61_ KVFFS 66_ RLIQI 71_ LKIMV 76_ PRTFC 81_ KETGY 86_ LVLIA 91_ VMLVS 96_ RTYCD 101_ VWMIQ 106_ NGTLI 111_ ESGII 116_ GRSRK 121_ DFKRY 126_ LLNFI 131_ AAMPL 136_ ISLVN 141_ NFLKY 146_ GLNEL 151_ KLCFR 156_ VRLTK 161_ YLYEE 166_ YLQAF 171_ TYYKM 176_ GNLDN 181_ RIANP 186_ DQLLT 191_ QDVEK 196_ FCNSV 201_ VDLYS 206_ NLSKP 211_ FLDIV 216_ LYIFK 221_ LTSAI 226_ GAQGP 231_ ASMMA 236_ YLVVS 241_ GLFLT 246_ RLRRP 251_ IGKMT 256_ ITEQK 261_ YEGEY 266_ RYVNS 271_ RLITN 276_ SEEIA 281_ FYNGN 286_ KREKQ 291_ TVHSV 296_ FRKLV 301_ EHLHN 306_ FILFR 311_ FSMGF 316_ IDSII 321_ AKYLA 326_ TVVGY 331_ LVVSR 336_ PFLDL 341_ SHPRH 346_ LKSTH 351_ SELLE 356_ DYYQS 361_ GRMLL 366_ RMSQA 371_ LGRIV 376_ LAGRE 381_ MTRLA 386_ GFTAR 391_ ITELM 396_ QVLKD 401_ LNHGK 406_ YERTM 411_ VSQQE 416_ KGIEG 421_ VQVIP 426_ LIPGA 431_ GEIII 436_ ADNII 441_ KFDHV 446_ PLATP 451_ NGDVL 456_ IRDLN 461_ FEVRS 466_ GANVL 471_ ICGPN 476_ GCGKS 481_ SLFRV 486_ LGELW 491_ PLFGG 496_ RLTKP 501_ ERGKL 506_ FYVPQ 511_ RPYMT 516_ LGTLR 521_ DQVIY 526_ PDGRE 531_ DQKRK 536_ GISDL 541_ VLKEY 546_ LDNVQ 551_ LGHIL 556_ EREGG 561_ WDSVQ 566_ DWMDV 571_ LSGGE 576_ KQRMA 581_ MARLF 586_ YHKPQ 591_ FAILD 596_ ECTSA 601_ VSVDV 606_ EGYIY 611_ SHCRK 616_ VGITL 621_ FTVSH 626_ RKSLW 631_ KHHEY 636_ YLHMD 641_ GRGNY 646_ EFKQI 651_TEDTV
1: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation (PubMed:11248239, PubMed:24333844, PubMed:25168382, PubMed:29397936). Has fatty acyl-CoA thioesterase and ATPase activities (PubMed:29397936). Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:24333844, PubMed:25944712)