Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
1_MSYRR 6_ ELEKY 11_ RDLDE 16_ DEILG 21_ ALTEE 26_ ELRTL 31_ ENELD 36_ ELDPD 41_ NALLP 46_ AGLRQ 51_ KDQTT 56_ KAPTG 61_ PFKRE 66_ ELLDH 71_ LEKQA 76_ KEFKD 81_ REDLV 86_ PYTGE 91_ KRGKV 96_ WVPKQ 101_ KPLDP 106_ VLESV 111_ TLEPE 116_ LEEAL 121_ ANASD 126_ AELCD 131_ IAAIL 136_ GMHTL 141_ MSNQQ 146_ YYQAL 151_ SSSSI 156_ MNKEG 161_ LNSVI 166_ KPTQY 171_ KPVPD 176_ EEPNS 181_ TDVEE 186_ TLERI 191_ KNNDP 196_ KLEEV 201_ NLNNI 206_ RNIPI 211_ PTLKA 216_ YAEAL 221_ KENSY 226_ VKKFS 231_ IVGTR 236_ SNDPV 241_ AYALA 246_ EMLKE 251_ NKVLK 256_ TLNVE 261_ SNFIS 266_ GAGIL 271_ RLVEA 276_ LPYNT 281_ SLVEM 286_ KIDNQ 291_ SQPLG 296_ NKVEM 301_ EIVSM 306_ LEKNA 311_ TLLKF 316_ GYHFT 321_ QQGPR 326_ LRASN 331_ AMMNN 336_ NDLVR 341_ KRRLA 346_ DLTGP 351_IIPKC
1: Blocks the elongation and depolymerization of the actin filaments at the pointed end (PubMed:38168645). The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus