ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1)
1_MDSAI 6_ TLWQF 11_ LLQLL 16_ QKPQN 21_ KHMIC 26_ WTSND 31_ GQFKL 36_ LQAEE 41_ VARLW 46_ GIRKN 51_ KPNMN 56_ YDKLS 61_ RALRY 66_ YYVKN 71_ IIKKV 76_ NGQKF 81_ VYKFV 86_ SYPEI 91_ LNMDP 96_ MTVGR 101_ IEGDC 106_ ESLNF 111_ SEVSS 116_ SSKDV 121_ ENGGK 126_ DKPPQ 131_ PGAKT 136_ SSRND 141_ YIHSG 146_ LYSSF 151_ TLNSL 156_ NSSNV 161_ KLFKL 166_ IKTEN 171_ PAEKL 176_ AEKKS 181_ PQEPT 186_ PSVIK 191_ FVTTP 196_ SKKPP 201_ VEPVA 206_ ATISI 211_ GPSIS 216_ PSSEE 221_ TIQAL 226_ ETLVS 231_ PKLPS 236_ LEAPT 241_ SASNV 246_ MTAFA 251_ TTPPI 256_ SSIPP 261_ LQEPP 266_ RTPSP 271_ PLSSH 276_ PDIDT 281_ DIDSV 286_ ASQPM 291_ ELPEN 296_ LSLEP 301_ KDQDS 306_ VLLEK 311_ DKVNN 316_ SSRSK 321_ KPKGL 326_ ELAPT 331_ LVITS 336_ SDPSP 341_ LGILS 346_ PSLPT 351_ ASLTP 356_ AFFSQ 361_ TPIIL 366_ TPSPL 371_ LSSIH 376_ FWSTL 381_ SPVAP 386_ LSPAR 391_ LQGAN 396_ TLFQF 401_ PSVLN 406_ SHGPF 411_ TLSGL 416_ DGPST 421_ PGPFS 426_PDLQK
1: Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously