Peroxisome biogenesis factor 2 (35 kDa peroxisomal membrane protein) (Peroxin-2) (Peroxisomal membrane protein 3) (Peroxisome assembly factor 1) (PAF-1) (RING finger protein 72)
1_MASRK 6_ ENAKS 11_ ANRVL 16_ RISQL 21_ DALEL 26_ NKALE 31_ QLVWS 36_ QFTQC 41_ FHGFK 46_ PGLLA 51_ RFEPE 56_ VKACL 61_ WVFLW 66_ RFTIY 71_ SKNAT 76_ VGQSV 81_ LNIKY 86_ KNDFS 91_ PNLRY 96_ QPPSK 101_ NQKIW 106_ YAVCT 111_ IGGRW 116_ LEERC 121_ YDLFR 126_ NHHLA 131_ SFGKV 136_ KQCVN 141_ FVIGL 146_ LKLGG 151_ LINFL 156_ IFLQR 161_ GKFAT 166_ LTERL 171_ LGIHS 176_ VFCKP 181_ QNICE 186_ VGFEY 191_ MNREL 196_ LWHGF 201_ AEFLI 206_ FLLPL 211_ INVQK 216_ LKAKL 221_ SSWCI 226_ PLTGA 231_ PNSDN 236_ TLATS 241_ GKECA 246_ LCGEW 251_ PTMPH 256_ TIGCE 261_ HIFCY 266_ FCAKS 271_ SFLFD 276_ VYFTC 281_ PKCGT 286_ EVHSL 291_ QPLKS 296_GIEMS
1: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity). PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity). Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70 (PubMed:27597759). Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis (PubMed:34903883)