Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC 1.3.8.8)
1_MAARL 6_ LRGSL 11_ RVLGG 16_ HRAPR 21_ QLPAA 26_ RCSHS 31_ GGEER 36_ LETPS 41_ AKKLT 46_ DIGIR 51_ RIFSP 56_ EHDIF 61_ RKSVR 66_ KFFQE 71_ EVIPH 76_ HSEWE 81_ KAGEV 86_ SREVW 91_ EKAGK 96_ QGLLG 101_ VNIAE 106_ HLGGI 111_ GGDLY 116_ SAAIV 121_ WEEQA 126_ YSNCS 131_ GPGFS 136_ IHSGI 141_ VMSYI 146_ TNHGS 151_ EEQIK 156_ HFIPQ 161_ MTAGK 166_ CIGAI 171_ AMTEP 176_ GAGSD 181_ LQGIK 186_ TNAKK 191_ DGSDW 196_ ILNGS 201_ KVFIS 206_ NGSLS 211_ DVVIV 216_ VAVTN 221_ HEAPS 226_ PAHGI 231_ SLFLV 236_ ENGMK 241_ GFIKG 246_ RKLHK 251_ MGLKA 256_ QDTAE 261_ LFFED 266_ IRLPA 271_ SALLG 276_ EENKG 281_ FYYIM 286_ KELPQ 291_ ERLLI 296_ ADVAI 301_ SASEF 306_ MFEET 311_ RNYVK 316_ QRKAF 321_ GKTVA 326_ HLQTV 331_ QHKLA 336_ ELKTH 341_ ICVTR 346_ AFVDN 351_ CLQLH 356_ EAKRL 361_ DSATA 366_ CMAKY 371_ WASEL 376_ QNSVA 381_ YDCVQ 386_ LHGGW 391_ GYMWE 396_ YPIAK 401_ AYVDA 406_ RVQPI 411_ YGGTN 416_ EIMKE 421_LIARE
1: Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (By similarity). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (PubMed:21237683, PubMed:8823175)