Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13)
1_MEPSS 6_ WSGSE 11_ SPAEN 16_ MERMS 21_ DSADK 26_ PIDND 31_ AEGVW 36_ SPDIE 41_ QSFQE 46_ ALAIY 51_ PPCGR 56_ RKIIL 61_ SDEGK 66_ MYGRN 71_ ELIAR 76_ YIKLR 81_ TGKTR 86_ TRKQV 91_ SSHIQ 96_ VLARR 101_ KSRDF 106_ HSKLK 111_ DQTAK 116_ DKALQ 121_ HMAAM 126_ SSAQI 131_ VSATA 136_ IHNKL 141_ GLPGI 146_ PRPTF 151_ PGAPG 156_ FWPGM 161_ IQTGQ 166_ PGSSQ 171_ DVKPF 176_ VQQAY 181_ PIQPA 186_ VTAPI 191_ PGFEP 196_ ASAPA 201_ PSVPA 206_ WQGRS 211_ IGTTK 216_ LRLVE 221_ FSAFL 226_ EQQRD 231_ PDSYN 236_ KHLFV 241_ HIGHA 246_ NHSYS 251_ DPLLE 256_ SVDIR 261_ QIYDK 266_ FPEKK 271_ GGLKE 276_ LFGKG 281_ PQNAF 286_ FLVKF 291_ WADLN 296_ CNIQD 301_ DAGAF 306_ YGVTS 311_ QYESS 316_ ENMTV 321_ TCSTK 326_ VCSFG 331_ KQVVE 336_ KVETE 341_ YARFE 346_ NGRFV 351_ YRINR 356_ SPMCE 361_ YMINF 366_ IHKLK 371_ HLPEK 376_ YMMNS 381_ VLENF 386_ TILLV 391_ VTNRD 396_ TQETL 401_ LCMAC 406_ VFEVS 411_ NSEHG 416_ AQHHI 421_YRLVK
1: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif