Homeobox protein MSX-1 (Homeobox protein Hox-7) (Msh homeobox 1-like protein)
1_MAPAA 6_ DMTSL 11_ PLGVK 16_ VEDSA 21_ FGKPA 26_ GGGAG 31_ QAPSA 36_ AAATA 41_ AAMGA 46_ DEEGA 51_ KPKVS 56_ PSLLP 61_ FSVEA 66_ LMADH 71_ RKPGA 76_ KESAL 81_ APSEG 86_ VQAAG 91_ GSAQP 96_ LGVPP 101_ GSLGA 106_ PDAPS 111_ SPRPL 116_ GHFSV 121_ GGLLK 126_ LPEDA 131_ LVKAE 136_ SPEKP 141_ ERTPW 146_ MQSPR 151_ FSPPP 156_ ARRLS 161_ PPACT 166_ LRKHK 171_ TNRKP 176_ RTPFT 181_ TAQLL 186_ ALERK 191_ FRQKQ 196_ YLSIA 201_ ERAEF 206_ SSSLS 211_ LTETQ 216_ VKIWF 221_ QNRRA 226_ KAKRL 231_ QEAEL 236_ EKLKM 241_ AAKPM 246_ LPPAA 251_ FGLSF 256_ PLGGP 261_ AAVAA 266_ AAGAS 271_ LYGAS 276_ GPFQR 281_ AALPV 286_ APVGL 291_ YTAHV 296_GYSMY
1: Acts as a transcriptional repressor (By similarity). Capable of transcription autoinactivation (By similarity). Binds to the consensus sequence 5'-C/GTAAT-3' in downstream activin regulatory elements (DARE) in the gene promoter, thereby repressing the transcription of CGA/alpha-GSU and GNRHR (By similarity). Represses transcription of myoblast differentiation factors (By similarity). Binds to core enhancer regions in target gene promoters of myoblast differentiation factors with binding specificity facilitated by interaction with PIAS1 (By similarity). Regulates, in a stage-specific manner, a developmental program of gene expression in the fetal tooth bud that controls odontoblast differentiation and proliferation of dental mesenchymal cells (By similarity). At the bud stage, required for mesenchymal molar tooth bud development via facilitating reciprocal signaling between dental epithelial and mesenchymal cells (By similarity). May also regulate expression of Wnt antagonists such as DKK2 and SFPR2 in the developing tooth mesenchyme (By similarity). Required for BMP4 expression in dental mesenchyme cells (By similarity). Also, in response to BMP4, required for BMP4 expression in neighboring dental epithelial cells (By similarity). Required for maximal FGF4-induced expression of SDC1 in dental mesenchyme cells (By similarity). Also in response to SDC1, required for SDC1 expression in neighboring dental epithelial cells (By similarity). At the early bell stage, acts to drive proliferation of dental mesenchyme cells, however during the late bell stage acts as an homeostatic regulator of the cell cycle (By similarity). Regulates proliferation and inhibits premature mesenchymal odontogenesis during the bell stage via inhibition of the Wnt signaling component CTNNB1 and subsequent repression of the odontoblast differentiation factors BMP2, BMP4, LEF1, ALPL and BGLAP/OCN (By similarity). Additionally, required for correct development and fusion of the palatal shelves and embryonic mandibular formation (By similarity). Plays a role in embryonic bone formation of the middle ear, skull and nasal bones (By similarity). Required for correct formation and thickness of the nail plate (By similarity). May play a role in limb-pattern formation (By similarity)