Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)
1_MEQDT 6_ AAVAA 11_ TVAAA 16_ DATAT 21_ IVVIE 26_ DEQPG 31_ PSTSQ 36_ EEGAA 41_ AAATE 46_ ATAAT 51_ EKGEK 56_ KKEKN 61_ VSSFQ 66_ LKLAA 71_ KAPKS 76_ EKEMD 81_ PEYEE 86_ KMKAD 91_ RAKRF 96_ EFLLK 101_ QTELF 106_ AHFIQ 111_ PSAQK 116_ SPTSP 121_ LNMKL 126_ GRPRI 131_ KKDEK 136_ QSLIS 141_ AGDYR 146_ HRRTE 151_ QEEDE 156_ ELLSE 161_ SRKTS 166_ NVCIR 171_ FEVSP 176_ SYVKG 181_ GPLRD 186_ YQIRG 191_ LNWLI 196_ SLYEN 201_ GVNGI 206_ LADEM 211_ GLGKT 216_ LQTIA 221_ LLGYL 226_ KHYRN 231_ IPGPH 236_ MVLVP 241_ KSTLH 246_ NWMNE 251_ FKRWV 256_ PSLRV 261_ ICFVG 266_ DKDAR 271_ AAFIR 276_ DEMMP 281_ GEWDV 286_ CVTSY 291_ EMVIK 296_ EKSVF 301_ KKFHW 306_ RYLVI 311_ DEAHR 316_ IKNEK 321_ SKLSE 326_ IVREF 331_ KSTNR 336_ LLLTG 341_ TPLQN 346_ NLHEL 351_ WALLN 356_ FLLPD 361_ VFNSA 366_ DDFDS 371_ WFDTK 376_ NCLGD 381_ QKLVE 386_ RLHAV 391_ LKPFL 396_ LRRIK 401_ TDVEK 406_ SLPPK 411_ KEIKI 416_ YLGLS 421_ KMQRE 426_ WYTKI 431_ LMKDI 436_ DVLNS 441_ SGKMD 446_ KMRLL 451_ NILMQ 456_ LRKCC 461_ NHPYL 466_ FDGAE 471_ PGPPY 476_ TTDEH 481_ IVSNS 486_ GKMVV 491_ LDKLL 496_ AKLKE 501_ QGSRV 506_ LIFSQ 511_ MTRLL 516_ DILED 521_ YCMWR 526_ GYEYC 531_ RLDGQ 536_ TPHEE 541_ REDKF 546_ LEVEF 551_ LGQRE 556_ AIEAF 561_ NAPNS 566_ SKFIF 571_ MLSTR 576_ AGGLG 581_ INLAS 586_ ADVVI 591_ LYDSD 596_ WNPQV 601_ DLQAM 606_ DRAHR 611_ IGQKK 616_ PVRVF 621_ RLITD 626_ NTVEE 631_ RIVER 636_ AEIKL 641_ RLDSI 646_ VIQQG 651_ RLIDQ 656_ QSNKL 661_ AKEEM 666_ LQMIR 671_ HGATH 676_ VFASK 681_ ESELT 686_ DEDIT 691_ TILER 696_ GEKKT 701_ AEMNE 706_ RLQKM 711_ GESSL 716_ RNFRM 721_ DIEQS 726_ LYKFE 731_ GEDYR 736_ EKQKL 741_ GMVEW 746_ IEPPK 751_ RERKA 756_ NYAVD 761_ AYFRE 766_ ALRVS 771_ EPKIP 776_ KAPRP 781_ PKQPN 786_ VQDFQ 791_ FFPPR 796_ LFELL 801_ EKEIL 806_ YYRKT 811_ IGYKV 816_ PRNPD 821_ IPNPA 826_ LAQRE 831_ EQKKI 836_ DGAEP 841_ LTPEE 846_ TEEKE 851_ KLLTQ 856_ GFTNW 861_ TKRDF 866_ NQFIK 871_ ANEKY 876_ GRDDI 881_ DNIAR 886_ EVEGK 891_ SPEEV 896_ MEYSA 901_ VFWER 906_ CNELQ 911_ DIEKI 916_ MAQIE 921_ RGEAR 926_ IQRRI 931_ SIKKA 936_ LDAKI 941_ ARYKA 946_ PFHQL 951_ RIQYG 956_ TSKGK 961_ NYTEE 966_ EDRFL 971_ ICMLH 976_ KMGFD 981_ RENVY 986_ EELRQ 991_ CVRNA 996_ PQFRF 1001_ DWFIK 1006_ SRTAM 1011_ EFQRR 1016_ CNTLI 1021_ SLIEK 1026_ ENMEI 1031_ EERER 1036_ AEKKK 1041_ RATKT 1046_PMVKF
1: ATPase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:14609955, PubMed:15310751, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). Facilitates nucleosome assembly during DNA replication, ensuring replication fork progression and genomic stability by preventing replication stress and nascent DNA gaps (PubMed:39413208)
2: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751)