Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3)
1_MWGLA 6_ GGRLF 11_ GIFSA 16_ PVLVA 21_ VVCCA 26_ QSVND 31_ PGNMS 36_ FVKET 41_ VDKLL 46_ KGYDI 51_ RLRPD 56_ FGGPP 61_ VCVGM 66_ NIDIA 71_ SIDMV 76_ SEVNM 81_ DYTLT 86_ MYFQQ 91_ YWRDK 96_ RLAYS 101_ GIPLN 106_ LTLDN 111_ RVADQ 116_ LWVPD 121_ TYFLN 126_ DKKSF 131_ VHGVT 136_ VKNRM 141_ IRLHP 146_ DGTVL 151_ YGLRI 156_ TTTAA 161_ CMMDL 166_ RRYPL 171_ DEQNC 176_ TLEIE 181_ SYGYT 186_ TDDIE 191_ FYWRG 196_ GDKAV 201_ TGVER 206_ IELPQ 211_ FSIVE 216_ HRLVS 221_ RNVVF 226_ ATGAY 231_ PRLSL 236_ SFRLK 241_ RNIGY 246_ FILQT 251_ YMPSI 256_ LITIL 261_ SWVSF 266_ WINYD 271_ ASAAR 276_ VALGI 281_ TTVLT 286_ MTTIN 291_ THLRE 296_ TLPKI 301_ PYVKA 306_ IDMYL 311_ MGCFV 316_ FVFLA 321_ LLEYA 326_ FVNYI 331_ FFGRG 336_ PQRQK 341_ KLAEK 346_ TAKAK 351_ NDRSK 356_ SESNR 361_ VDAHG 366_ NILLT 371_ SLEVH 376_ NEMNE 381_ VSGGI 386_ GDTRN 391_ SAISF 396_ DNSGI 401_ QYRKQ 406_ SMPRE 411_ GHGRF 416_ LGDRS 421_ LPHKK 426_ THLRR 431_ RSSQL 436_ KIKIP 441_ DLTDV 446_ NAIDR 451_ WSRIV 456_ FPFTF 461_ SLFNL 466_VYWLY
1: Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:18514161, PubMed:22243422, PubMed:22303015, PubMed:24909990, PubMed:26950270, PubMed:30602789). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:24909990, PubMed:30140029, PubMed:30602789). GABAARs containing beta-3/GABRB3 subunit are found at both synaptic and extrasynaptic sites (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:14993607, PubMed:22303015, PubMed:26950270, PubMed:30602789). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:22303015, PubMed:26950270). GABAARs containing alpha-1 and beta-3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:25489750). Extrasynaptic beta-3 receptors contribute to the tonic GABAergic inhibition (By similarity). GABAARs containing alpha-1, beta-3 and epsilon subunits may also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (By similarity). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (PubMed:18281286, PubMed:24909990, PubMed:35355020). Plays an important role in somatosensation and in the production of antinociception (By similarity)