Gamma-aminobutyric acid receptor subunit rho-2 (GABA(A) receptor subunit rho-2) (GABA(C) receptor)
1_MPYFT 6_ RLILF 11_ LFCLM 16_ VLVES 21_ RKPKR 26_ KRWTG 31_ QVEMP 36_ KPSHL 41_ YKKNL 46_ DVTKI 51_ RKGKP 56_ QQLLR 61_ VDEHD 66_ FSMRP 71_ AFGGP 76_ AIPVG 81_ VDVQV 86_ ESLDS 91_ ISEVD 96_ MDFTM 101_ TLYLR 106_ HYWKD 111_ ERLAF 116_ SSASN 121_ KSMTF 126_ DGRLV 131_ KKIWV 136_ PDVFF 141_ VHSKR 146_ SFTHD 151_ TTTDN 156_ IMLRV 161_ FPDGH 166_ VLYSM 171_ RITVT 176_ AMCNM 181_ DFSHF 186_ PLDSQ 191_ TCSLE 196_ LESYA 201_ YTDED 206_ LMLYW 211_ KNGDE 216_ SLKTD 221_ EKISL 226_ SQFLI 231_ QKFHT 236_ TSRLA 241_ FYSST 246_ GWYNR 251_ LYINF 256_ TLRRH 261_ IFFFL 266_ LQTYF 271_ PATLM 276_ VMLSW 281_ VSFWI 286_ DRRAV 291_ PARVS 296_ LGITT 301_ VLTMT 306_ TIITG 311_ VNASM 316_ PRVSY 321_ VKAVD 326_ IYLWV 331_ SFVFV 336_ FLSVL 341_ EYAAV 346_ NYLTT 351_ VQERK 356_ ERKLR 361_ EKFPC 366_ MCGML 371_ HSKTM 376_ MLDGS 381_ YSESE 386_ ANSLA 391_ GYPRS 396_ HILTE 401_ EERQD 406_ KIVVH 411_ LGLSG 416_ EANAA 421_ RKKGL 426_ LKGQT 431_ GFRIF 436_ QNTHA 441_ IDKYS 446_ RLIFP 451_ ASYIF 456_FNLIY
1: Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (By similarity). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Rho-2 GABAARs may contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission. Rho-2 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). Rho-2 GABAARs expressed in retina may play a role in retinal neurotransmission (By similarity)