5-hydroxytryptamine receptor 1E (5-HT-1E) (5-HT1E) (S31) (Serotonin receptor 1E)
1_MNITN 6_ CTTEA 11_ SMAIR 16_ PKTIT 21_ EKMLI 26_ CMTLV 31_ VITTL 36_ TTLLN 41_ LAVIM 46_ AIGTT 51_ KKLHQ 56_ PANYL 61_ ICSLA 66_ VTDLL 71_ VAVLV 76_ MPLSI 81_ IYIVM 86_ DRWKL 91_ GYFLC 96_ EVWLS 101_ VDMTC 106_ CTCSI 111_ LHLCV 116_ IALDR 121_ YWAIT 126_ NAIEY 131_ ARKRT 136_ AKRAA 141_ LMILT 146_ VWTIS 151_ IFISM 156_ PPLFW 161_ RSHRR 166_ LSPPP 171_ SQCTI 176_ QHDHV 181_ IYTIY 186_ STLGA 191_ FYIPL 196_ TLILI 201_ LYYRI 206_ YHAAK 211_ SLYQK 216_ RGSSR 221_ HLSNR 226_ STDSQ 231_ NSFAS 236_ CKLTQ 241_ TFCVS 246_ DFSTS 251_ DPTTE 256_ FEKFH 261_ ASIRI 266_ PPFDN 271_ DLDHP 276_ GERQQ 281_ ISSTR 286_ ERKAA 291_ RILGL 296_ ILGAF 301_ ILSWL 306_ PFFIK 311_ ELIVG 316_ LSIYT 321_ VSSEV 326_ ADFLT 331_ WLGYV 336_ NSLIN 341_ PLLYT 346_ SFNED 351_ FKLAF 356_KKLIR
1: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:14744596, PubMed:1513320, PubMed:1608964, PubMed:1733778, PubMed:21422162, PubMed:33762731). Also functions as a receptor for various alkaloids and psychoactive substances (PubMed:14744596, PubMed:1513320, PubMed:1608964, PubMed:1733778, PubMed:21422162, PubMed:33762731). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:14744596, PubMed:1513320, PubMed:1608964, PubMed:1733778, PubMed:21422162, PubMed:33762731). HTR1E is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:33762731, PubMed:35610220)