DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (Xeroderma pigmentosum group G-complementing protein)
1_MGVQG 6_ LWKLL 11_ ECSGR 16_ QVSPE 21_ ALEGK 26_ ILAVD 31_ ISIWL 36_ NQALK 41_ GVRDR 46_ HGNSI 51_ ENPHL 56_ LTLFH 61_ RLCKL 66_ LFFRI 71_ RPIFV 76_ FDGDA 81_ PLLKK 86_ QTLVK 91_ RRQRK 96_ DLASS 101_ DSRKT 106_ TEKLL 111_ KTFLK 116_ RQAIK 121_ TAFRS 126_ KRDEA 131_ LPSLT 136_ QVRRE 141_ NDLYV 146_ LPPLQ 151_ EEEKH 156_ SSEEE 161_ DEKEW 166_ QERMN 171_ QKQAL 176_ QEEFF 181_ HNPQA 186_ IDIES 191_ EDFSS 196_ LPPEV 201_ KHEIL 206_ TDMKE 211_ FTKRR 216_ RTLFE 221_ AMPEE 226_ SDDFS 231_ QYQLK 236_ GLLKK 241_ NYLNQ 246_ HIEHV 251_ QKEMN 256_ QQHSG 261_ HIRRQ 266_ YEDEG 271_ GFLKE 276_ VESRR 281_ VVSED 286_ TSHYI 291_ LIKGI 296_ QAKTV 301_ AEVDS 306_ ESLPS 311_ SSKMH 316_ GMSFD 321_ VKSSP 326_ CEKLK 331_ TEKEP 336_ DATPP 341_ SPRTL 346_ LAMQA 351_ ALLGS 356_ SSEEE 361_ LESEN 366_ RRQAR 371_ GRNAP 376_ AAVDE 381_ GSISP 386_ RTLSA 391_ IKRAL 396_ DDDED 401_ VKVCA 406_ GDDVQ 411_ TGGPG 416_ AEEMR 421_ INSST 426_ ENSDE 431_ GLKVR 436_ DGKGI 441_ PFTAT 446_ LASSS 451_ VNSAE 456_ EHVAS 461_ TNEGR 466_ EPTDS 471_ VPKEQ 476_ MSLVH 481_ VGTEA 486_ FPISD 491_ ESMIK 496_ DRKDR 501_ LPLES 506_ AVVRH 511_ SDAPG 516_ LPNGR 521_ ELTPA 526_ SPTCT 531_ NSVSK 536_ NETHA 541_ EVLEQ 546_ QNELC 551_ PYESK 556_ FDSSL 561_ LSSDD 566_ ETKCK 571_ PNSAS 576_ EVIGP 581_ VSLQE 586_ TSSIV 591_ SVPSE 596_ AVDNV 601_ ENVVS 606_ FNAKE 611_ HENFL 616_ ETIQE 621_ QQTTE 626_ SAGQD 631_ LISIP 636_ KAVEP 641_ MEIDS 646_ EESES 651_ DGSFI 656_ EVQSV 661_ ISDEE 666_ LQAEF 671_ PETSK 676_ PPSEQ 681_ GEEEL 686_ VGTRE 691_ GEAPA 696_ ESESL 701_ LRDNS 706_ ERDDV 711_ DGEPQ 716_ EAEKD 721_ AEDSL 726_ HEWQD 731_ INLEE 736_ LETLE 741_ SNLLA 746_ QQNSL 751_ KAQKQ 756_ QQERI 761_ AATVT 766_ GQMFL 771_ ESQEL 776_ LRLFG 781_ IPYIQ 786_ APMEA 791_ EAQCA 796_ ILDLT 801_ DQTSG 806_ TITDD 811_ SDIWL 816_ FGARH 821_ VYRNF 826_ FNKNK 831_ FVEYY 836_ QYVDF 841_ HNQLG 846_ LDRNK 851_ LINLA 856_ YLLGS 861_ DYTEG 866_ IPTVG 871_ CVTAM 876_ EILNE 881_ FPGHG 886_ LEPLL 891_ KFSEW 896_ WHEAQ 901_ KNPKI 906_ RPNPH 911_ DTKVK 916_ KKLRT 921_ LQLTP 926_ GFPNP 931_ AVAEA 936_ YLKPV 941_ VDDSK 946_ GSFLW 951_ GKPDL 956_ DKIRE 961_ FCQRY 966_ FGWNR 971_ TKTDE 976_ SLFPV 981_ LKQLD 986_ AQQTQ 991_ LRIDS 996_ FFRLA 1001_ QQEKE 1006_ DAKRI 1011_ KSQRL 1016_ NRAVT 1021_ CMLRK 1026_ EKEAA 1031_ ASEIE 1036_ AVSVA 1041_ MEKEF 1046_ ELLDK 1051_ AKGKT 1056_ QKRGI 1061_ TNTLE 1066_ ESSSL 1071_ KRKRL 1076_ SDSKG 1081_ KNTCG 1086_ GFLGE 1091_ TCLSE 1096_ SSDGS 1101_ SSEDA 1106_ ESSSL 1111_ MNVQR 1116_ RTAAK 1121_ EPKTS 1126_ ASDSQ 1131_ NSVKE 1136_ APVKN 1141_ GGATT 1146_ SSSSD 1151_ SDDDG 1156_ GKEKM 1161_ VLVTA 1166_ RSVFG 1171_ KKRRK 1176_ LRRAR 1181_GRKRK
1: Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090)