Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)
1_MFEDK 6_ PHAEG 11_ AAVVA 16_ AAGEA 21_ LQALC 26_ QELNL 31_ DEGSA 36_ AEALD 41_ DFTAI 46_ RGNYS 51_ LEGEV 56_ THWLA 61_ CSLYV 66_ ACRKS 71_ IIPTV 76_ GKGIM 81_ EGNCV 86_ SLTRI 91_ LRSAK 96_ LSLIQ 101_ FFSKM 106_ KKWMD 111_ MSNLP 116_ QEFRE 121_ RIERL 126_ ERNFE 131_ VSTVI 136_ FKKYE 141_ PIFLD 146_ IFQNP 151_ YEEPP 156_ KLPRS 161_ RKQRR 166_ IPCSV 171_ KDLFN 176_ FCWTL 181_ FVYTK 186_ GNFRM 191_ IGDDL 196_ VNSYH 201_ LLLCC 206_ LDLIF 211_ ANAIM 216_ CPNRQ 221_ DLLNP 226_ SFKGL 231_ PSDFH 236_ TADFT 241_ ASEEP 246_ PCIIA 251_ VLCEL 256_ HDGLL 261_ VEAKG 266_ IKEHY 271_ FKPYI 276_ SKLFD 281_ RKILK 286_ GECLL 291_ DLSSF 296_ TDNSK 301_ AVNKE 306_ YEEYV 311_ LTVGD 316_ FDERI 321_ FLGAD 326_ AEEEI 331_ GTPRK 336_ FTRDT 341_ PLGKL 346_ TAQAN 351_ VEYNL 356_ QQHFE 361_ KKRSF 366_ APSTP 371_ LTGRR 376_ YLREK 381_ EAVIT 386_ PVASA 391_ TQSVS 396_ RLQSI 401_ VAGLK 406_ NAPSD 411_ QLINI 416_ FESCV 421_ RNPVE 426_ NIMKI 431_ LKGIG 436_ ETFCQ 441_ HYTQS 446_ TDEQP 451_ GSHID 456_ FAVNR 461_ LKLAE 466_ ILYYK 471_ ILETV 476_ MVQET 481_ RRLHG 486_ MDMSV 491_ LLEQD 496_ IFHRS 501_ LMACC 506_ LEIVL 511_ FAYSS 516_ PRTFP 521_ WIIEV 526_ LNLQP 531_ FYFYK 536_ VIEVV 541_ IRSEE 546_ GLSRD 551_ MVKHL 556_ NSIEE 561_ QILES 566_ LAWSH 571_ DSALW 576_ EALQV 581_ SANKV 586_ PTCEE 591_ VIFPN 596_ NFETG 601_ NGGNV 606_ QGHLP 611_ LMPMS 616_ PLMHP 621_ RVKEV 626_ RTDSG 631_ SLRRD 636_ MQPLS 641_ PISVH 646_ ERYSS 651_ PTAGS 656_ AKRRL 661_ FGEDP 666_ PKEML 671_ MDKII 676_ TEGTK 681_ LKIAP 686_ SSSIT 691_ AENVS 696_ ILPGQ 701_ TLLTM 706_ ATAPV 711_ TGTTG 716_ HKVTI 721_ PLHGV 726_ ANDAG 731_ EITLI 736_ PLSMN 741_ TNQES 746_ KVKSP 751_ VSLTA 756_ HSLIG 761_ ASPKQ 766_ TNLTK 771_ AQEVH 776_ STGIN 781_ RPKRT 786_ GSLAL 791_ FYRKV 796_ YHLAS 801_ VRLRD 806_ LCLKL 811_ DVSNE 816_ LRRKI 821_ WTCFE 826_ FTLVH 831_ CPDLM 836_ KDRHL 841_ DQLLL 846_ CAFYI 851_ MAKVT 856_ KEERT 861_ FQEIM 866_ KSYRN 871_ QPQAN 876_ SHVYR 881_ SVLLK 886_ SIPRE 891_ VVAYN 896_ KNIND 901_ DFEMI 906_ DCDLE 911_ DATKT 916_ PDCSS 921_ GPVKE 926_ ERGDL 931_ IKFYN 936_ TIYVG 941_ RVKSF 946_ ALKYD 951_ LANQD 956_ HMMDA 961_ PPLSP 966_ FPHIK 971_ QQPGS 976_ PRRIS 981_ QQHSI 986_ YISPH 991_ KNGSG 996_ LTPRS 1001_ ALLYK 1006_ FNGSP 1011_ SKSLK 1016_ DINNM 1021_ IRQGE 1026_ QRTKK 1031_ RVIAI 1036_ DSDAE 1041_ SPAKR 1046_ VCQEN 1051_ DDVLL 1056_ KRLQD 1061_VVSER
1: Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904)