Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]
1_MWTLV 6_ SWVAL 11_ TAGLV 16_ AGTRC 21_ PDGQF 26_ CPVAC 31_ CLDPG 36_ GASYS 41_ CCRPL 46_ LDKWP 51_ TTLSR 56_ HLGGP 61_ CQVDA 66_ HCSAG 71_ HSCIF 76_ TVSGT 81_ SSCCP 86_ FPEAV 91_ ACGDG 96_ HHCCP 101_ RGFHC 106_ SADGR 111_ SCFQR 116_ SGNNS 121_ VGAIQ 126_ CPDSQ 131_ FECPD 136_ FSTCC 141_ VMVDG 146_ SWGCC 151_ PMPQA 156_ SCCED 161_ RVHCC 166_ PHGAF 171_ CDLVH 176_ TRCIT 181_ PTGTH 186_ PLAKK 191_ LPAQR 196_ TNRAV 201_ ALSSS 206_ VMCPD 211_ ARSRC 216_ PDGST 221_ CCELP 226_ SGKYG 231_ CCPMP 236_ NATCC 241_ SDHLH 246_ CCPQD 251_ TVCDL 256_ IQSKC 261_ LSKEN 266_ ATTDL 271_ LTKLP 276_ AHTVG 281_ DVKCD 286_ MEVSC 291_ PDGYT 296_ CCRLQ 301_ SGAWG 306_ CCPFT 311_ QAVCC 316_ EDHIH 321_ CCPAG 326_ FTCDT 331_ QKGTC 336_ EQGPH 341_ QVPWM 346_ EKAPA 351_ HLSLP 356_ DPQAL 361_ KRDVP 366_ CDNVS 371_ SCPSS 376_ DTCCQ 381_ LTSGE 386_ WGCCP 391_ IPEAV 396_ CCSDH 401_ QHCCP 406_ QGYTC 411_ VAEGQ 416_ CQRGS 421_ EIVAG 426_ LEKMP 431_ ARRAS 436_ LSHPR 441_ DIGCD 446_ QHTSC 451_ PVGQT 456_ CCPSL 461_ GGSWA 466_ CCQLP 471_ HAVCC 476_ EDRQH 481_ CCPAG 486_ YTCNV 491_ KARSC 496_ EKEVV 501_ SAQPA 506_ TFLAR 511_ SPHVG 516_ VKDVE 521_ CGEGH 526_ FCHDN 531_ QTCCR 536_ DNRQG 541_ WACCP 546_ YRQGV 551_ CCADR 556_ RHCCP 561_ AGFRC 566_ AARGT 571_ KCLRR 576_ EAPRW 581_ DAPLR 586_DPALR
1: Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:12526812, PubMed:18378771, PubMed:28073925, PubMed:28453791, PubMed:28541286). Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286). Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:18378771)
2: Promotes proliferation of the epithelial cell line A431 in culture
3: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8
4: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity