Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase)
1_MFLLP 6_ LPAAG 11_ RVVVR 16_ RLAVR 21_ RFGSR 26_ SLSTA 31_ DMTKG 36_ LVLGI 41_ YSKEK 46_ EDDVP 51_ QFTSA 56_ GENFD 61_ KLLAG 66_ KLRET 71_ LNISG 76_ PPLKA 81_ GKTRT 86_ FYGLH 91_ QDFPS 96_ VVLVG 101_ LGKKA 106_ AGIDE 111_ QENWH 116_ EGKEN 121_ IRAAV 126_ AAGCR 131_ QIQDL 136_ ELSSV 141_ EVDPC 146_ GDAQA 151_ AAEGA 156_ VLGLY 161_ EYDDL 166_ KQKKK 171_ MAVSA 176_ KLYGS 181_ GDQEA 186_ WQKGV 191_ LFASG 196_ QNLAR 201_ QLMET 206_ PANEM 211_ TPTRF 216_ AEIIE 221_ KNLKS 226_ ASSKT 231_ EVHIR 236_ PKSWI 241_ EEQAM 246_ GSFLS 251_ VAKGS 256_ DEPPV 261_ FLEIH 266_ YKGSP 271_ NANEP 276_ PLVFV 281_ GKGIT 286_ FDSGG 291_ ISIKA 296_ SANMD 301_ LMRAD 306_ MGGAA 311_ TICSA 316_ IVSAA 321_ KLNLP 326_ INIIG 331_ LAPLC 336_ ENMPS 341_ GKANK 346_ PGDVV 351_ RAKNG 356_ KTIQV 361_ DNTDA 366_ EGRLI 371_ LADAL 376_ CYAHT 381_ FNPKV 386_ ILNAA 391_ TLTGA 396_ MDVAL 401_ GSGAT 406_ GVFTN 411_ SSWLW 416_ NKLFE 421_ ASIET 426_ GDRVW 431_ RMPLF 436_ EHYTR 441_ QVVDC 446_ QLADV 451_ NNIGK 456_ YRSAG 461_ ACTAA 466_ AFLKE 471_ FVTHP 476_ KWAHL 481_ DIAGV 486_ MTNKD 491_ EVPYL 496_ RKGMT 501_ GRPTR 506_ TLIEF 511_LLRFS
1: Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status