ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (T10) (CD antigen CD38)
1_MANCE 6_ FSPVS 11_ GDKPC 16_ CRLSR 21_ RAQLC 26_ LGVSI 31_ LVLIL 36_ VVVLA 41_ VVVPR 46_ WRQQW 51_ SGPGT 56_ TKRFP 61_ ETVLA 66_ RCVKY 71_ TEIHP 76_ EMRHV 81_ DCQSV 86_ WDAFK 91_ GAFIS 96_ KHPCN 101_ ITEED 106_ YQPLM 111_ KLGTQ 116_ TVPCN 121_ KILLW 126_ SRIKD 131_ LAHQF 136_ TQVQR 141_ DMFTL 146_ EDTLL 151_ GYLAD 156_ DLTWC 161_ GEFNT 166_ SKINY 171_ QSCPD 176_ WRKDC 181_ SNNPV 186_ SVFWK 191_ TVSRR 196_ FAEAA 201_ CDVVH 206_ VMLNG 211_ SRSKI 216_ FDKNS 221_ TFGSV 226_ EVHNL 231_ QPEKV 236_ QTLEA 241_ WVIHG 246_ GREDS 251_ RDLCQ 256_ DPTIK 261_ ELESI 266_ ISKRN 271_ IQFSC 276_ KNIYR 281_ PDKFL 286_ QCVKN 291_PEDSS
1: Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion (PubMed:7961800, PubMed:8253715). Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+) (PubMed:16690024). Has cADPR hydrolase activity (PubMed:7961800, PubMed:8253715)