Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1)
1_MTSRF 6_ RLPAG 11_ RTYNV 16_ RASEL 21_ ARDRQ 26_ HTEVV 31_ CNILL 36_ LDNTV 41_ QAFKV 46_ NKHDQ 51_ GQVLL 56_ DVVFK 61_ HLDLT 66_ EQDYF 71_ GLQLA 76_ DDSTD 81_ NPRWL 86_ DPNKP 91_ IRKQL 96_ KRGSP 101_ YSLNF 106_ RVKFF 111_ VSDPN 116_ KLQEE 121_ YTRYQ 126_ YFLQI 131_ KQDIL 136_ TGRLP 141_ CPSNT 146_ AALLA 151_ SFAVQ 156_ SELGD 161_ YDQSE 166_ NLSGY 171_ LSDYS 176_ FIPNQ 181_ PQDFE 186_ KEIAK 191_ LHQQH 196_ IGLSP 201_ AEAEF 206_ NYLNT 211_ ARTLE 216_ LYGVE 221_ FHYAR 226_ DQSNN 231_ EIMIG 236_ VMSGG 241_ ILIYK 246_ NRVRM 251_ NTFPW 256_ LKIVK 261_ ISFKC 266_ KQFFI 271_ QLRKE 276_ LHESR 281_ ETLLG 286_ FNMVN 291_ YRACK 296_ NLWKA 301_ CVEHH 306_ TFFRL 311_ DRPLP 316_ PQKNF 321_ FAHYF 326_ TLGSK 331_ FRYCG 336_ RTEVQ 341_ SVQYG 346_ KEKAN 351_ KDRVF 356_ ARSPS 361_ KPLAR 366_ KLMDW 371_ EVVSR 376_ NSISD 381_ DRLET 386_ QSLPS 391_ RSPPG 396_ TPNHR 401_ NSTFT 406_ QEGTR 411_ LRPSS 416_ VGHLV 421_ DHMVH 426_ TSPSE 431_ VFVNQ 436_ RSPSS 441_ TQANS 446_ IVLES 451_ SPSQE 456_ TPGDG 461_ KPPAL 466_ PPKQS 471_ KKNSW 476_ NQIHY 481_ SHSQQ 486_ DLESH 491_ INETF 496_ DIPSS 501_ PEKPT 506_ PNGGI 511_ PHDNL 516_ VLIRM 521_ KPDEN 526_ GRFGF 531_ NVKGG 536_ YDQKM 541_ PVIVS 546_ RVAPG 551_ TPADL 556_ CVPRL 561_ NEGDQ 566_ VVLIN 571_ GRDIA 576_ EHTHD 581_ QVVLF 586_ IKASC 591_ ERHSG 596_ ELMLL 601_ VRPNA 606_ VYDVV 611_ EEKLE 616_ NEPDF 621_ QYIPE 626_ KAPLD 631_ SVHQD 636_ DHSLR 641_ ESMIQ 646_ LAEGL 651_ ITGTV 656_ LTQFD 661_ QLYRK 666_ KPGMT 671_ MSCAK 676_ LPQNI 681_ SKNRY 686_ RDISP 691_ YDATR 696_ VILKG 701_ NEDYI 706_ NANYI 711_ NMEIP 716_ SSSII 721_ NQYIA 726_ CQGPL 731_ PHTCT 736_ DFWQM 741_ TWEQG 746_ SSMVV 751_ MLTTQ 756_ VERGR 761_ VKCHQ 766_ YWPEP 771_ TGSSS 776_ YGCYQ 781_ VTCHS 786_ EEGNT 791_ AYIFR 796_ KMTLF 801_ NQEKN 806_ ESRPL 811_ TQIQY 816_ IAWPD 821_ HGVPD 826_ DSSDF 831_ LDFVC 836_ HVRNK 841_ RAGKE 846_ EPVVV 851_ HCSAG 856_ IGRTG 861_ VLITM 866_ ETAMC 871_ LIECN 876_ QPVYP 881_ LDIVR 886_ TMRDQ 891_ RAMMI 896_ QTPSQ 901_ YRFVC 906_ EAILK 911_ VYEEG 916_ FVKPL 921_TTSTN
1: Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:25825441, PubMed:27246854). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (PubMed:20086240). Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed:25825441). Also dephosphorylates the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity). May act at junctions between the membrane and the cytoskeleton