Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4)
1_MPPRA 6_ PPAPG 11_ PRPPP 16_ RAAAA 21_ TDTAA 26_ GAGGA 31_ GGAGG 36_ AGGPG 41_ FRPLA 46_ PRPWR 51_ WLLLL 56_ ALPAA 61_ CSAPP 66_ PRPVY 71_ TNHWA 76_ VQVLG 81_ GPAEA 86_ DRVAA 91_ AHGYL 96_ NLGQI 101_ GNLED 106_ YYHFY 111_ HSKTF 116_ KRSTL 121_ SSRGP 126_ HTFLR 131_ MDPQV 136_ KWLQQ 141_ QEVKR 146_ RVKRQ 151_ VRSDP 156_ QALYF 161_ NDPIW 166_ SNMWY 171_ LHCGD 176_ KNSRC 181_ RSEMN 186_ VQAAW 191_ KRGYT 196_ GKNVV 201_ VTILD 206_ DGIER 211_ NHPDL 216_ APNYD 221_ SYASY 226_ DVNGN 231_ DYDPS 236_ PRYDA 241_ SNENK 246_ HGTRC 251_ AGEVA 256_ ASANN 261_ SYCIV 266_ GIAYN 271_ AKIGG 276_ IRMLD 281_ GDVTD 286_ VVEAK 291_ SLGIR 296_ PNYID 301_ IYSAS 306_ WGPDD 311_ DGKTV 316_ DGPGR 321_ LAKQA 326_ FEYGI 331_ KKGRQ 336_ GLGSI 341_ FVWAS 346_ GNGGR 351_ EGDYC 356_ SCDGY 361_ TNSIY 366_ TISVS 371_ SATEN 376_ GYKPW 381_ YLEEC 386_ ASTLA 391_ TTYSS 396_ GAFYE 401_ RKIVT 406_ TDLRQ 411_ RCTDG 416_ HTGTS 421_ VSAPM 426_ VAGII 431_ ALALE 436_ ANSQL 441_ TWRDV 446_ QHLLV 451_ KTSRP 456_ AHLKA 461_ SDWKV 466_ NGAGH 471_ KVSHF 476_ YGFGL 481_ VDAEA 486_ LVVEA 491_ KKWTA 496_ VPSQH 501_ MCVAA 506_ SDKRP 511_ RSIPL 516_ VQVLR 521_ TTALT 526_ SACAE 531_ HSDQR 536_ VVYLE 541_ HVVVR 546_ TSISH 551_ PRRGD 556_ LQIYL 561_ VSPSG 566_ TKSQL 571_ LAKRL 576_ LDLSN 581_ EGFTN 586_ WEFMT 591_ VHCWG 596_ EKAEG 601_ QWTLE 606_ IQDLP 611_ SQVRN 616_ PEKQG 621_ KLKEW 626_ SLILY 631_ GTAEH 636_ PYHTF 641_ SAHQS 646_ RSRML 651_ ELSAP 656_ ELEPP 661_ KAALS 666_ PSQVE 671_ VPEDE 676_ EDYTA 681_ QSTPG 686_ SANIL 691_ QTSVC 696_ HPECG 701_ DKGCD 706_ GPNAD 711_ QCLNC 716_ VHFSL 721_ GSVKT 726_ SRKCV 731_ SVCPL 736_ GYFGD 741_ TAARR 746_ CRRCH 751_ KGCET 756_ CSSRA 761_ ATQCL 766_ SCRRG 771_ FYHHQ 776_ EMNTC 781_ VTLCP 786_ AGFYA 791_ DESQK 796_ NCLKC 801_ HPSCK 806_ KCVDE 811_ PEKCT 816_ VCKEG 821_ FSLAR 826_ GSCIP 831_ DCEPG 836_ TYFDS 841_ ELIRC 846_ GECHH 851_ TCGTC 856_ VGPGR 861_ EECIH 866_ CAKNF 871_ HFHDW 876_ KCVPA 881_ CGEGF 886_ YPEEM 891_ PGLPH 896_ KVCRR 901_ CDENC 906_ LSCAG 911_ SSRNC 916_ SRCKT 921_ GFTQL 926_ GTSCI 931_ TNHTC 936_ SNADE 941_ TFCEM 946_ VKSNR 951_ LCERK 956_ LFIQF 961_CCRTC
1: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues