Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
1_MDCQL 6_ SILLL 11_ LSCSV 16_ LDSFG 21_ ELIPQ 26_ PSNEV 31_ NLLDS 36_ KTIQG 41_ ELGWI 46_ SYPSH 51_ GWEEI 56_ SGVDE 61_ HYTPI 66_ RTYQV 71_ CNVMD 76_ HSQNN 81_ WLRTN 86_ WVPRN 91_ SAQKI 96_ YVELK 101_ FTLRD 106_ CNSIP 111_ LVLGT 116_ CKETF 121_ NLYYM 126_ ESDDD 131_ HGVKF 136_ REHQF 141_ TKIDT 146_ IAADE 151_ SFTQM 156_ DLGDR 161_ ILKLN 166_ TEIRE 171_ VGPVN 176_ KKGFY 181_ LAFQD 186_ VGACV 191_ ALVSV 196_ RVYFK 201_ KCPFT 206_ VKNLA 211_ MFPDT 216_ VPMDS 221_ QSLVE 226_ VRGSC 231_ VNNSK 236_ EEDPP 241_ RMYCS 246_ TEGEW 251_ LVPIG 256_ KCSCN 261_ AGYEE 266_ RGFMC 271_ QACRP 276_ GFYKA 281_ LDGNM 286_ KCAKC 291_ PPHSS 296_ TQEDG 301_ SMNCR 306_ CENNY 311_ FRADK 316_ DPPSM 321_ ACTRP 326_ PSSPR 331_ NVISN 336_ INETS 341_ VILDW 346_ SWPLD 351_ TGGRK 356_ DVTFN 361_ IICKK 366_ CGWNI 371_ KQCEP 376_ CSPNV 381_ RFLPR 386_ QFGLT 391_ NTTVT 396_ VTDLL 401_ AHTNY 406_ TFEID 411_ AVNGV 416_ SELSS 421_ PPRQF 426_ AAVSI 431_ TTNQA 436_ APSPV 441_ LTIKK 446_ DRTSR 451_ NSISL 456_ SWQEP 461_ EHPNG 466_ IILDY 471_ EVKYY 476_ EKQEQ 481_ ETSYT 486_ ILRAR 491_ GTNVT 496_ ISSLK 501_ PDTIY 506_ VFQIR 511_ ARTAA 516_ GYGTN 521_ SRKFE 526_ FETSP 531_ DSFSI 536_ SGESS 541_ QVVMI 546_ AISAA 551_ VAIIL 556_ LTVVI 561_ YVLIG 566_ RFCGY 571_ KSKHG 576_ ADEKR 581_ LHFGN 586_ GHLKL 591_ PGLRT 596_ YVDPH 601_ TYEDP 606_ TQAVH 611_ EFAKE 616_ LDATN 621_ ISIDK 626_ VVGAG 631_ EFGEV 636_ CSGRL 641_ KLPSK 646_ KEISV 651_ AIKTL 656_ KVGYT 661_ EKQRR 666_ DFLGE 671_ ASIMG 676_ QFDHP 681_ NIIRL 686_ EGVVT 691_ KSKPV 696_ MIVTE 701_ YMENG 706_ SLDSF 711_ LRKHD 716_ AQFTV 721_ IQLVG 726_ MLRGI 731_ ASGMK 736_ YLSDM 741_ GYVHR 746_ DLAAR 751_ NILIN 756_ SNLVC 761_ KVSDF 766_ GLSRV 771_ LEDDP 776_ EAAYT 781_ TRGGK 786_ IPIRW 791_ TSPEA 796_ IAYRK 801_ FTSAS 806_ DVWSY 811_ GIVLW 816_ EVMSY 821_ GERPY 826_ WEMSN 831_ QDVIK 836_ AVDEG 841_ YRLPP 846_ PMDCP 851_ AALYQ 856_ LMLDC 861_ WQKDR 866_ NNRPK 871_ FEQIV 876_ SILDK 881_ LIRNP 886_ GSLKI 891_ ITSAA 896_ ARPSN 901_ LLLDQ 906_ SNVDI 911_ TTFRT 916_ TGDWL 921_ NGVWT 926_ AHCKE 931_ IFTGV 936_ EYSSC 941_ DTIAK 946_ ISTDD 951_ MKKVG 956_ VTVVG 961_ PQKKI 966_ ISSIK 971_ ALETQ 976_SKNGP
1: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development