Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK)
1_MAPAR 6_ GRLPP 11_ ALWVV 16_ TAAAA 21_ AATCV 26_ SAARG 31_ EVNLL 36_ DTSTI 41_ HGDWG 46_ WLTYP 51_ AHGWD 56_ SINEV 61_ DESFQ 66_ PIHTY 71_ QVCNV 76_ MSPNQ 81_ NNWLR 86_ TSWVP 91_ RDGAR 96_ RVYAE 101_ IKFTL 106_ RDCNS 111_ MPGVL 116_ GTCKE 121_ TFNLY 126_ YLESD 131_ RDLGA 136_ STQES 141_ QFLKI 146_ DTIAA 151_ DESFT 156_ GADLG 161_ VRRLK 166_ LNTEV 171_ RSVGP 176_ LSKRG 181_ FYLAF 186_ QDIGA 191_ CLAIL 196_ SLRIY 201_ YKKCP 206_ AMVRN 211_ LAAFS 216_ EAVTG 221_ ADSSS 226_ LVEVR 231_ GQCVR 236_ HSEER 241_ DTPKM 246_ YCSAE 251_ GEWLV 256_ PIGKC 261_ VCSAG 266_ YEERR 271_ DACVA 276_ CELGF 281_ YKSAP 286_ GDQLC 291_ ARCPP 296_ HSHSA 301_ APAAQ 306_ ACHCD 311_ LSYYR 316_ AALDP 321_ PSSAC 326_ TRPPS 331_ APVNL 336_ ISSVN 341_ GTSVT 346_ LEWAP 351_ PLDPG 356_ GRSDI 361_ TYNAV 366_ CRRCP 371_ WALSR 376_ CEACG 381_ SGTRF 386_ VPQQT 391_ SLVQA 396_ SLLVA 401_ NLLAH 406_ MNYSF 411_ WIEAV 416_ NGVSD 421_ LSPEP 426_ RRAAV 431_ VNITT 436_ NQAAP 441_ SQVVV 446_ IRQER 451_ AGQTS 456_ VSLLW 461_ QEPEQ 466_ PNGII 471_ LEYEI 476_ KYYEK 481_ DKEMQ 486_ SYSTL 491_ KAVTT 496_ RATVS 501_ GLKPG 506_ TRYVF 511_ QVRAR 516_ TSAGC 521_ GRFSQ 526_ AMEVE 531_ TGKPR 536_ PRYDT 541_ RTIVW 546_ ICLTL 551_ ITGLV 556_ VLLLL 561_ LICKK 566_ RHCGY 571_ SKAFQ 576_ DSDEE 581_ KMHYQ 586_ NGQAP 591_ PPVFL 596_ PLHHP 601_ PGKLP 606_ EPQFY 611_ AEPHT 616_ YEEPG 621_ RAGRS 626_ FTREI 631_ EASRI 636_ HIEKI 641_ IGSGD 646_ SGEVC 651_ YGRLR 656_ VPGQR 661_ DVPVA 666_ IKALK 671_ AGYTE 676_ RQRRD 681_ FLSEA 686_ SIMGQ 691_ FDHPN 696_ IIRLE 701_ GVVTR 706_ GRLAM 711_ IVTEY 716_ MENGS 721_ LDTFL 726_ RTHDG 731_ QFTIM 736_ QLVGM 741_ LRGVG 746_ AGMRY 751_ LSDLG 756_ YVHRD 761_ LAARN 766_ VLVDS 771_ NLVCK 776_ VSDFG 781_ LSRVL 786_ EDDPD 791_ AAYTT 796_ TGGKI 801_ PIRWT 806_ APEAI 811_ AFRTF 816_ SSASD 821_ VWSFG 826_ VVMWE 831_ VLAYG 836_ ERPYW 841_ NMTNR 846_ DVISS 851_ VEEGY 856_ RLPAP 861_ MGCPH 866_ ALHQL 871_ MLDCW 876_ HKDRA 881_ QRPRF 886_ SQIVS 891_ VLDAL 896_ IRSPE 901_ SLRAT 906_ ATVSR 911_ CPPPA 916_ FVRSC 921_ FDLRG 926_ GSGGG 931_ GGLTV 936_ GDWLD 941_ SIRMG 946_ RYRDH 951_ FAAGG 956_ YSSLG 961_ MVLRM 966_ NAQDV 971_ RALGI 976_ TLMGH 981_ QKKIL 986_ GSIQT 991_ MRAQL 996_TSTQG
1: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity)