Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)
1_MVRWF 6_ HRDLS 11_ GLDAE 16_ TLLKG 21_ RGVHG 26_ SFLAR 31_ PSRKN 36_ QGDFS 41_ LSVRV 46_ GDQVT 51_ HIRIQ 56_ NSGDF 61_ YDLYG 66_ GEKFA 71_ TLTEL 76_ VEYYT 81_ QQQGV 86_ LQDRD 91_ GTIIH 96_ LKYPL 101_ NCSDP 106_ TSERW 111_ YHGHM 116_ SGGQA 121_ ETLLQ 126_ AKGEP 131_ WTFLV 136_ RESLS 141_ QPGDF 146_ VLSVL 151_ SDQPK 156_ AGPGS 161_ PLRVT 166_ HIKVM 171_ CEGGR 176_ YTVGG 181_ LETFD 186_ SLTDL 191_ VEHFK 196_ KTGIE 201_ EASGA 206_ FVYLR 211_ QPYYA 216_ TRVNA 221_ ADIEN 226_ RVLEL 231_ NKKQE 236_ SEDTA 241_ KAGFW 246_ EEFES 251_ LQKQE 256_ VKNLH 261_ QRLEG 266_ QRPEN 271_ KGKNR 276_ YKNIL 281_ PFDHS 286_ RVILQ 291_ GRDSN 296_ IPGSD 301_ YINAN 306_ YIKNQ 311_ LLGPD 316_ ENAKT 321_ YIASQ 326_ GCLEA 331_ TVNDF 336_ WQMAW 341_ QENSR 346_ VIVMT 351_ TREVE 356_ KGRNK 361_ CVPYW 366_ PEVGM 371_ QRAYG 376_ PYSVT 381_ NCGEH 386_ DTTEY 391_ KLRTL 396_ QVSPL 401_ DNGDL 406_ IREIW 411_ HYQYL 416_ SWPDH 421_ GVPSE 426_ PGGVL 431_ SFLDQ 436_ INQRQ 441_ ESLPH 446_ AGPII 451_ VHCSA 456_ GIGRT 461_ GTIIV 466_ IDMLM 471_ ENIST 476_ KGLDC 481_ DIDIQ 486_ KTIQM 491_ VRAQR 496_ SGMVQ 501_ TEAQY 506_ KFIYV 511_ AIAQF 516_ IETTK 521_ KKLEV 526_ LQSQK 531_ GQESE 536_ YGNIT 541_ YPPAM 546_ KNAHA 551_ KASRT 556_ SSKHK 561_ EDVYE 566_ NLHTK 571_ NKREE 576_ KVKKQ 581_ RSADK 586_EKSKG
1: Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871)