SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
1_MDLLP 6_ PKPKY 11_ NPLRN 16_ ESLSS 21_ LEEGA 26_ SGSTP 31_ PEELP 36_ SPSAS 41_ SLGPI 46_ LPPLP 51_ GDDSP 56_ TTLCS 61_ FFPRM 66_ SNLRL 71_ ANPAG 76_ GRPGS 81_ KGEPG 86_ RAADD 91_ GEGIV 96_ GAAMP 101_ DSGPL 106_ PLLQD 111_ MNKLS 116_ GGGGR 121_ RTRVE 126_ GGQLG 131_ GEEWT 136_ RHGSF 141_ VNKPT 146_ RGWLH 151_ PNDKV 156_ MGPGV 161_ SYLVR 166_ YMGCV 171_ EVLQS 176_ MRALD 181_ FNTRT 186_ QVTRE 191_ AISLV 196_ CEAVP 201_ GAKGA 206_ TRRRK 211_ PCSRP 216_ LSSIL 221_ GRSNL 226_ KFAGM 231_ PITLT 236_ VSTSS 241_ LNLMA 246_ ADCKQ 251_ IIANH 256_ HMQSI 261_ SFASG 266_ GDPDT 271_ AEYVA 276_ YVAKD 281_ PVNQR 286_ ACHIL 291_ ECPEG 296_ LAQDV 301_ ISTIG 306_ QAFEL 311_ RFKQY 316_ LRNPP 321_ KLVTP 326_ HDRMA 331_ GFDGS 336_ AWDEE 341_ EEEPP 346_ DHQYY 351_ NDFPG 356_ KEPPL 361_ GGVVD 366_ MRLRE 371_ GAAPG 376_ AARPT 381_ APNAQ 386_ TPSHL 391_ GATLP 396_ VGQPV 401_ GGDPE 406_ VRKQM 411_ PPPPP 416_ CPGRE 421_ LFDDP 426_ SYVNV 431_ QNLDK 436_ ARQAV 441_ GGAGP 446_ PNPAI 451_ NGSAP 456_ RDLFD 461_ MKPFE 466_ DALRV 471_ PPPPQ 476_ SVSMA 481_ EQLRG 486_ EPWFH 491_ GKLSR 496_ REAEA 501_ LLQLN 506_ GDFLV 511_ RESTT 516_ TPGQY 521_ VLTGL 526_ QSGQP 531_ KHLLL 536_ VDPEG 541_ VVRTK 546_ DHRFE 551_ SVSHL 556_ ISYHM 561_ DNHLP 566_ IISAG 571_ SELCL 576_QQPVE
1: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis