Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A)
1_MAGVG 6_ PGGYA 11_ AEFVP 16_ PPECP 21_ VFEPS 26_ WEEFT 31_ DPLSF 36_ IGRIR 41_ PLAEK 46_ TGICK 51_ IRPPK 56_ DWQPP 61_ FACEV 66_ KSFRF 71_ TPRVQ 76_ RLNEL 81_ EAMTR 86_ VRLDF 91_ LDQLA 96_ KFWEL 101_ QGSTL 106_ KIPVV 111_ ERKIL 116_ DLYAL 121_ SKIVA 126_ SKGGF 131_ EMVTK 136_ EKKWS 141_ KVGSR 146_ LGYLP 151_ GKGTG 156_ SLLKS 161_ HYERI 166_ LYPYE 171_ LFQSG 176_ VSLMG 181_ VQMPN 186_ LDLKE 191_ KVEPE 196_ VLSTD 201_ TQTSP 206_ EPGTR 211_ MNILP 216_ KRTRR 221_ VKTQS 226_ ESGDV 231_ SRNTE 236_ LKKLQ 241_ IFGAG 246_ PKVVG 251_ LAMGT 256_ KDKED 261_ EVTRR 266_ RKVTN 271_ RSDAF 276_ NMQMR 281_ QRKGT 286_ LSVNF 291_ VDLYV 296_ CMFCG 301_ RGNNE 306_ DKLLL 311_ CDGCD 316_ DSYHT 321_ FCLIP 326_ PLPDV 331_ PKGDW 336_ RCPKC 341_ VAEEC 346_ SKPRE 351_ AFGFE 356_ QAVRE 361_ YTLQS 366_ FGEMA 371_ DNFKS 376_ DYFNM 381_ PVHMV 386_ PTELV 391_ EKEFW 396_ RLVSS 401_ IEEDV 406_ IVEYG 411_ ADISS 416_ KDFGS 421_ GFPVK 426_ DGRRK 431_ ILPEE 436_ EEYAL 441_ SGWNL 446_ NNMPV 451_ LEQSV 456_ LAHIN 461_ VDISG 466_ MKVPW 471_ LYVGM 476_ CFSSF 481_ CWHIE 486_ DHWSY 491_ SINYL 496_ HWGEP 501_ KTWYG 506_ VPSHA 511_ AEQLE 516_ EVMRE 521_ LAPEL 526_ FESQP 531_ DLLHQ 536_ LVTIM 541_ NPNVL 546_ MEHGV 551_ PVYRT 556_ NQCAG 561_ EFVVT 566_ FPRAY 571_ HSGFN 576_ QGYNF 581_ AEAVN 586_ FCTAD 591_ WLPIG 596_ RQCVN 601_ HYRRL 606_ RRHCV 611_ FSHEE 616_ LIFKM 621_ AADPE 626_ CLDVG 631_ LAAMV 636_ CKELT 641_ LMTEE 646_ ETRLR 651_ ESVVQ 656_ MGVLM 661_ SEEEV 666_ FELVP 671_ DDERQ 676_ CSACR 681_ TTCFL 686_ SALTC 691_ SCNPE 696_ RLVCL 701_ YHPTD 706_ LCPCP 711_ MQKKC 716_ LRYRY 721_ PLEDL 726_ PSLLY 731_ GVKVR 736_ AQSYD 741_ TWVSR 746_ VTEAL 751_ SANFN 756_ HKKDL 761_ IELRV 766_ MLEDA 771_ EDRKY 776_ PENDL 781_ FRKLR 786_ DAVKE 791_ AETCA 796_ SVAQL 801_ LLSKK 806_ QKHRQ 811_ SPDSG 816_ RTRTK 821_ LTVEE 826_ LKAFV 831_ QQLFS 836_ LPCVI 841_ SQARQ 846_ VKNLL 851_ DDVEE 856_ FHERA 861_ QEAMM 866_ DETPD 871_ SSKLQ 876_ MLIDM 881_ GSSLY 886_ VELPE 891_ LPRLK 896_ QELQQ 901_ ARWLD 906_ EVRLT 911_ LSDPQ 916_ QVTLD 921_ VMKKL 926_ IDSGV 931_ GLAPH 936_ HAVEK 941_ AMAEL 946_ QELLT 951_ VSERW 956_ EEKAK 961_ VCLQA 966_ RPRHS 971_ VASLE 976_ SIVNE 981_ AKNIP 986_ AFLPN 991_ VLSLK 996_ EALQK 1001_ AREWT 1006_ AKVEA 1011_ IQSGS 1016_ NYAYL 1021_ EQLES 1026_ LSAKG 1031_ RPIPV 1036_ RLEAL 1041_ PQVES 1046_ QVAAA 1051_ RAWRE 1056_ RTGRT 1061_ FLKKN 1066_ SSHTL 1071_ LQVLS 1076_ PRTDI 1081_ GVYGS 1086_ GKNRR 1091_ KKVKE 1096_ LIEKE 1101_ KEKDL 1106_ DLEPL 1111_ SDLEE 1116_ GLEET 1121_ RDTAM 1126_ VVAVF 1131_ KEREQ 1136_ KEIEA 1141_ MHSLR 1146_ AANLA 1151_ KMTMV 1156_ DRIEE 1161_ VKFCI 1166_ CRKTA 1171_ SGFML 1176_ QCELC 1181_ KDWFH 1186_ NSCVP 1191_ LPKSS 1196_ SQKKG 1201_ SSWQA 1206_ KEVKF 1211_ LCPLC 1216_ MRSRR 1221_ PRLET 1226_ ILSLL 1231_ VSLQK 1236_ LPVRL 1241_ PEGEA 1246_ LQCLT 1251_ ERAMS 1256_ WQDRA 1261_ RQALA 1266_ TDELS 1271_ SALAK 1276_ LSVLS 1281_ QRMVE 1286_ QAARE 1291_ KTEKI 1296_ ISAEL 1301_ QKAAA 1306_ NPDLQ 1311_ GHLPS 1316_ FQQSA 1321_ FNRVV 1326_ SSVSS 1331_ SPRQT 1336_ MDYDD 1341_ EETDS 1346_ DEDIR 1351_ ETYGY 1356_ DMKDT 1361_ ASVKS 1366_ SSSLE 1371_ PNLFC 1376_ DEEIP 1381_ IKSEE 1386_ VVTHM 1391_ WTAPS 1396_ FCAEH 1401_ AYSSA 1406_ SKSCS 1411_ QGSST 1416_ PRKQP 1421_ RKSPL 1426_ VPRSL 1431_ EPPVL 1436_ ELSPG 1441_ AKAQL 1446_ EELMM 1451_ VGDLL 1456_ EVSLD 1461_ ETQHI 1466_ WRILQ 1471_ ATHPP 1476_ SEDRF 1481_ LHIME 1486_ DDSME 1491_ EKPLK 1496_ VKGKD 1501_ SSEKK 1506_ RKRKL 1511_ EKVEQ 1516_ LFGEG 1521_ KQKSK 1526_ ELKKM 1531_ DKPRK 1536_ KKLKL 1541_ GADKS 1546_ KELNK 1551_ LAKKL 1556_ AKEEE 1561_ RKKKK 1566_ EKAAA 1571_ AKVEL 1576_ VKEST 1581_ EKKRE 1586_ KKVLD 1591_ IPSKY 1596_ DWSGA 1601_ EESDD 1606_ ENAVC 1611_ AAQNC 1616_ QRPCK 1621_ DKVDW 1626_ VQCDG 1631_ GCDEW 1636_ FHQVC 1641_ VGVSP 1646_ EMAEN 1651_ EDYIC 1656_ INCAK 1661_ KQGPV 1666_ SPGPA 1671_ PPPSF 1676_ IMSYK 1681_LPMED
1: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228)