Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)
1_MGCWG 6_ QLLVW 11_ FGAAG 16_ AILCS 21_ SPGSQ 26_ ETFLR 31_ SSPLP 36_ LASPS 41_ PRDPK 46_ VSAPP 51_ SILEP 56_ ASPLN 61_ SPGTE 66_ GSWLF 71_ STCGA 76_ SGRHG 81_ PTQTQ 86_ CDGAY 91_ AGTSV 96_ VVTVG 101_ AAGQL 106_ RGVQL 111_ WRVPG 116_ PGQYL 121_ ISAYG 126_ AAGGK 131_ GAKNH 136_ LSRAH 141_ GVFVS 146_ AIFSL 151_ GLGES 156_ LYILV 161_ GQQGE 166_ DACPG 171_ GSPES 176_ QLVCL 181_ GESRA 186_ VEEHA 191_ AMDGS 196_ EGVPG 201_ SRRWA 206_ GGGGG 211_ GGGAT 216_ YVFRV 221_ RAGEL 226_ EPLLV 231_ AAGGG 236_ GRAYL 241_ RPRDR 246_ GRTQA 251_ SPEKL 256_ ENRSE 261_ APGSG 266_ GRGGA 271_ AGGGG 276_ GWTSR 281_ APSPQ 286_ AGRSL 291_ QEGAE 296_ GGQGC 301_ SEAWA 306_ TLGWA 311_ AAGGF 316_ GGGGG 321_ ACTAG 326_ GGGGG 331_ YRGGD 336_ ASETD 341_ NLWAD 346_ GEDGV 351_ SFIHP 356_ SSELF 361_ LQPLA 366_ VTENH 371_ GEVEI 376_ RRHLN 381_ CSHCP 386_ LRDCQ 391_ WQAEL 396_ QLAEC 401_ LCPEG 406_ MELAV 411_ DNVTC 416_ MDLHK 421_ PPGPL 426_ VLMVA 431_ VVATS 436_ TLSLL 441_ MVCGV 446_ LILVK 451_ QKKWQ 456_ GLQEM 461_ RLPSP 466_ ELELS 471_ KLRTS 476_ AIRTA 481_ PNPYY 486_ CQVGL 491_ GPAQS 496_ WPLPP 501_ GVTEV 506_ SPANV 511_ TLLRA 516_ LGHGA 521_ FGEVY 526_ EGLVI 531_ GLPGD 536_ SSPLQ 541_ VAIKT 546_ LPELC 551_ SPQDE 556_ LDFLM 561_ EALII 566_ SKFRH 571_ QNIVR 576_ CVGLS 581_ LRATP 586_ RLILL 591_ ELMSG 596_ GDMKS 601_ FLRHS 606_ RPHLG 611_ QPSPL 616_ VMRDL 621_ LQLAQ 626_ DIAQG 631_ CHYLE 636_ ENHFI 641_ HRDIA 646_ ARNCL 651_ LSCAG 656_ PSRVA 661_ KIGDF 666_ GMARD 671_ IYRAS 676_ YYRRG 681_ DRALL 686_ PVKWM 691_ PPEAF 696_ LEGIF 701_ TSKTD 706_ SWSFG 711_ VLLWE 716_ IFSLG 721_ YMPYP 726_ GRTNQ 731_ EVLDF 736_ VVGGG 741_ RMDPP 746_ RGCPG 751_ PVYRI 756_ MTQCW 761_ QHEPE 766_ LRPSF 771_ ASILE 776_ RLQYC 781_ TQDPD 786_ VLNSL 791_ LPMEL 796_ GPTPE 801_ EEGTS 806_ GLGNR 811_ SLECL 816_ RPPQP 821_ QELSP 826_ EKLKS 831_ WGGSP 836_ LGPWL 841_ SSGLK 846_ PLKSR 851_ GLQPQ 856_NLWNP
1: Receptor with a tyrosine-protein kinase activity (PubMed:10445845, PubMed:20548102, PubMed:30061385). Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:34646012). Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:20548102). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (By similarity). The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival (PubMed:18849880, PubMed:9223670). Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (PubMed:20548102)