Interleukin-12 subunit alpha (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (IL-12 subunit p35) (NK cell stimulatory factor chain 1) (NKSF1)
1_MCPAR 6_ SLLLV 11_ ATLVL 16_ LDHLS 21_ LARNL 26_ PVATP 31_ DPGMF 36_ PCLHH 41_ SQNLL 46_ RAVSN 51_ MLQKA 56_ RQTLE 61_ FYPCT 66_ SEEID 71_ HEDIT 76_ KDKTS 81_ TVEAC 86_ LPLEL 91_ TKNES 96_ CLNSR 101_ ETSFI 106_ TNGSC 111_ LASRK 116_ TSFMM 121_ ALCLS 126_ SIYED 131_ LKMYQ 136_ VEFKT 141_ MNAKL 146_ LMDPK 151_ RQIFL 156_ DQNML 161_ AVIDE 166_ LMQAL 171_ NFNSE 176_ TVPQK 181_ SSLEE 186_ PDFYK 191_ TKIKL 196_ CILLH 201_ AFRIR 206_ AVTID 211_RVMSY
1: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine (PubMed:8605935, PubMed:8943050). IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity (PubMed:1673147, PubMed:1674604, PubMed:8605935). Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits (PubMed:8943050). Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2 (PubMed:7528775). In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (PubMed:7638186). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and also functions as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers (PubMed:22306691). Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (PubMed:22306691)