Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40) (NK cell stimulatory factor chain 2) (NKSF2)
1_MCHQQ 6_ LVISW 11_ FSLVF 16_ LASPL 21_ VAIWE 26_ LKKDV 31_ YVVEL 36_ DWYPD 41_ APGEM 46_ VVLTC 51_ DTPEE 56_ DGITW 61_ TLDQS 66_ SEVLG 71_ SGKTL 76_ TIQVK 81_ EFGDA 86_ GQYTC 91_ HKGGE 96_ VLSHS 101_ LLLLH 106_ KKEDG 111_ IWSTD 116_ ILKDQ 121_ KEPKN 126_ KTFLR 131_ CEAKN 136_ YSGRF 141_ TCWWL 146_ TTIST 151_ DLTFS 156_ VKSSR 161_ GSSDP 166_ QGVTC 171_ GAATL 176_ SAERV 181_ RGDNK 186_ EYEYS 191_ VECQE 196_ DSACP 201_ AAEES 206_ LPIEV 211_ MVDAV 216_ HKLKY 221_ ENYTS 226_ SFFIR 231_ DIIKP 236_ DPPKN 241_ LQLKP 246_ LKNSR 251_ QVEVS 256_ WEYPD 261_ TWSTP 266_ HSYFS 271_ LTFCV 276_ QVQGK 281_ SKREK 286_ KDRVF 291_ TDKTS 296_ ATVIC 301_ RKNAS 306_ ISVRA 311_ QDRYY 316_ SSSWS 321_EWASV
1: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC
2: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis