Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
1_MADKV 6_ LKEKR 11_ KLFIR 16_ SMGEG 21_ TINGL 26_ LDELL 31_ QTRVL 36_ NKEEM 41_ EKVKR 46_ ENATV 51_ MDKTR 56_ ALIDS 61_ VIPKG 66_ AQACQ 71_ ICITY 76_ ICEED 81_ SYLAG 86_ TLGLS 91_ ADQTS 96_ GNYLN 101_ MQDSQ 106_ GVLSS 111_ FPAPQ 116_ AVQDN 121_ PAMPT 126_ SSGSE 131_ GNVKL 136_ CSLEE 141_ AQRIW 146_ KQKSA 151_ EIYPI 156_ MDKSS 161_ RTRLA 166_ LIICN 171_ EEFDS 176_ IPRRT 181_ GAEVD 186_ ITGMT 191_ MLLQN 196_ LGYSV 201_ DVKKN 206_ LTASD 211_ MTTEL 216_ EAFAH 221_ RPEHK 226_ TSDST 231_ FLVFM 236_ SHGIR 241_ EGICG 246_ KKHSE 251_ QVPDI 256_ LQLNA 261_ IFNML 266_ NTKNC 271_ PSLKD 276_ KPKVI 281_ IIQAC 286_ RGDSP 291_ GVVWF 296_ KDSVG 301_ VSGNL 306_ SLPTT 311_ EEFED 316_ DAIKK 321_ AHIEK 326_ DFIAF 331_ CSSTP 336_ DNVSW 341_ RHPTM 346_ GSVFI 351_ GRLIE 356_ HMQEY 361_ ACSCD 366_ VEEIF 371_ RKVRF 376_ SFEQP 381_ DGRAQ 386_ MPTTE 391_ RVTLT 396_RCFYL
1: Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides (PubMed:15326478, PubMed:15498465, PubMed:1574116, PubMed:26375003, PubMed:32051255, PubMed:37993714, PubMed:7876192, PubMed:9334240). Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes (PubMed:15326478, PubMed:15498465, PubMed:1574116, PubMed:32051255, PubMed:7876192). Cleaves a tetrapeptide after an Asp residue at position P1 (PubMed:15498465, PubMed:1574116, PubMed:7876192). Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD (PubMed:26375003). In contrast to cleavage of interleukin IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32051255, PubMed:32109412, PubMed:32553275). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (PubMed:22464733). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590). In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly (PubMed:20197547)
2: Apoptosis inactive
3: Apoptosis inactive