Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)
1_MPLRH 6_ WGMAR 11_ GSKPV 16_ GDGAQ 21_ PMAAM 26_ GGLKV 31_ LLHWA 36_ GPGGG 41_ EPWVT 46_ FSESS 51_ LTAEE 56_ VCIHI 61_ AHKVG 66_ ITPPC 71_ FNLFA 76_ LFDAQ 81_ AQVWL 86_ PPNHI 91_ LEIPR 96_ DASLM 101_ LYFRI 106_ RFYFR 111_ NWHGM 116_ NPREP 121_ AVYRC 126_ GPPGT 131_ EASSD 136_ QTAQG 141_ MQLLD 146_ PASFE 151_ YLFEQ 156_ GKHEF 161_ VNDVA 166_ SLWEL 171_ STEEE 176_ IHHFK 181_ NESLG 186_ MAFLH 191_ LCHLA 196_ LRHGI 201_ PLEEV 206_ AKKTS 211_ FKDCI 216_ PRSFR 221_ RHIRQ 226_ HSALT 231_ RLRLR 236_ NVFRR 241_ FLRDF 246_ QPGRL 251_ SQQMV 256_ MVKYL 261_ ATLER 266_ LAPRF 271_ GTERV 276_ PVCHL 281_ RLLAQ 286_ AEGEP 291_ CYIRD 296_ SGVAP 301_ TDPGP 306_ ESAAG 311_ PPTHE 316_ VLVTG 321_ TGGIQ 326_ WWPVE 331_ EEVNK 336_ EEGSS 341_ GSSGR 346_ NPQAS 351_ LFGKK 356_ AKAHK 361_ AVGQP 366_ ADRPR 371_ EPLWA 376_ YFCDF 381_ RDITH 386_ VVLKE 391_ HCVSI 396_ HRQDN 401_ KCLEL 406_ SLPSR 411_ AAALS 416_ FVSLV 421_ DGYFR 426_ LTADS 431_ SHYLC 436_ HEVAP 441_ PRLVM 446_ SIRDG 451_ IHGPL 456_ LEPFV 461_ QAKLR 466_ PEDGL 471_ YLIHW 476_ STSHP 481_ YRLIL 486_ TVAQR 491_ SQAPD 496_ GMQSL 501_ RLRKF 506_ PIEQQ 511_ DGAFV 516_ LEGWG 521_ RSFPS 526_ VRELG 531_ AALQG 536_ CLLRA 541_ GDDCF 546_ SLRRC 551_ CLPQP 556_ GETSN 561_ LIIMR 566_ GARAS 571_ PRTLN 576_ LSQLS 581_ FHRVD 586_ QKEIT 591_ QLSHL 596_ GQGTR 601_ TNVYE 606_ GRLRV 611_ EGSGD 616_ PEEGK 621_ MDDED 626_ PLVPG 631_ RDRGQ 636_ ELRVV 641_ LKVLD 646_ PSHHD 651_ IALAF 656_ YETAS 661_ LMSQV 666_ SHTHL 671_ AFVHG 676_ VCVRG 681_ PENIM 686_ VTEYV 691_ EHGPL 696_ DVWLR 701_ RERGH 706_ VPMAW 711_ KMVVA 716_ QQLAS 721_ ALSYL 726_ ENKNL 731_ VHGNV 736_ CGRNI 741_ LLARL 746_ GLAEG 751_ TSPFI 756_ KLSDP 761_ GVGLG 766_ ALSRE 771_ ERVER 776_ IPWLA 781_ PECLP 786_ GGANS 791_ LSTAM 796_ DKWGF 801_ GATLL 806_ EICFD 811_ GEAPL 816_ QSRSP 821_ SEKEH 826_ FYQRQ 831_ HRLPE 836_ PSCPQ 841_ LATLT 846_ SQCLT 851_ YEPTQ 856_ RPSFR 861_ TILRD 866_ LTRLQ 871_ PHNLA 876_ DVLTV 881_ NPDSP 886_ ASDPT 891_ VFHKR 896_ YLKKI 901_ RDLGE 906_ GHFGK 911_ VSLYC 916_ YDPTN 921_ DGTGE 926_ MVAVK 931_ ALKAD 936_ CGPQH 941_ RSGWK 946_ QEIDI 951_ LRTLY 956_ HEHII 961_ KYKGC 966_ CEDQG 971_ EKSLQ 976_ LVMEY 981_ VPLGS 986_ LRDYL 991_ PRHSI 996_ GLAQL 1001_ LLFAQ 1006_ QICEG 1011_ MAYLH 1016_ AQHYI 1021_ HRDLA 1026_ ARNVL 1031_ LDNDR 1036_ LVKIG 1041_ DFGLA 1046_ KAVPE 1051_ GHEYY 1056_ RVRED 1061_ GDSPV 1066_ FWYAP 1071_ ECLKE 1076_ YKFYY 1081_ ASDVW 1086_ SFGVT 1091_ LYELL 1096_ THCDS 1101_ SQSPP 1106_ TKFLE 1111_ LIGIA 1116_ QGQMT 1121_ VLRLT 1126_ ELLER 1131_ GERLP 1136_ RPDKC 1141_ PCEVY 1146_ HLMKN 1151_ CWETE 1156_ ASFRP 1161_ TFENL 1166_ IPILK 1171_ TVHEK 1176_ YQGQA 1181_PSVFS
1: Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:25762719, PubMed:7526154, PubMed:7813427). In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (PubMed:7526154, PubMed:7657660). In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (PubMed:10542297, PubMed:25762719, PubMed:7657660). Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862)