Gene name: SERPINA4

Uniprot entry:

P29622

Protein names:

Kallistatin (Kallikrein inhibitor) (Peptidase inhibitor 4) (PI-4) (Serpin A4)

Protein sequence:

1_MHLID 6_ YLLLL 11_ LVGLL 16_ ALSHG 21_ QLHVE 26_ HDGES 31_ CSNSS 36_ HQQIL 41_ ETGEG 46_ SPSLK 51_ IAPAN 56_ ADFAF 61_ RFYYL 66_ IASET 71_ PGKNI 76_ FFSPL 81_ SISAA 86_ YAMLS 91_ LGACS 96_ HSRSQ 101_ ILEGL 106_ GFNLT 111_ ELSES 116_ DVHRG 121_ FQHLL 126_ HTLNL 131_ PGHGL 136_ ETRVG 141_ SALFL 146_ SHNLK 151_ FLAKF 156_ LNDTM 161_ AVYEA 166_ KLFHT 171_ NFYDT 176_ VGTIQ 181_ LINDH 186_ VKKET 191_ RGKIV 196_ DLVSE 201_ LKKDV 206_ LMVLV 211_ NYIYF 216_ KALWE 221_ KPFIS 226_ SRTTP 231_ KDFYV 236_ DENTT 241_ VRVPM 246_ MLQDQ 251_ EHHWY 256_ LHDRY 261_ LPCSV 266_ LRMDY 271_ KGDAT 276_ VFFIL 281_ PNQGK 286_ MREIE 291_ EVLTP 296_ EMLMR 301_ WNNLL 306_ RKRNF 311_ YKKLE 316_ LHLPK 321_ FSISG 326_ SYVLD 331_ QILPR 336_ LGFTD 341_ LFSKW 346_ ADLSG 351_ ITKQQ 356_ KLEAS 361_ KSFHK 366_ ATLDV 371_ DEAGT 376_ EAAAA 381_ TSFAI 386_ KFFSA 391_ QTNRH 396_ ILRFN 401_ RPFLV 406_ VIFST 411_ STQSV 416_ LFLGK 421_VVDPT

Protein annotations

Protein functions:

1: Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein