2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS)
1_MGNGE 6_ SQLSS 11_ VPAQK 16_ LGWFI 21_ QEYLK 26_ PYEEC 31_ QTLID 36_ EMVNT 41_ ICDVL 46_ QEPEQ 51_ FPLVQ 56_ GVAIG 61_ GSYGR 66_ KTVLR 71_ GNSDG 76_ TLVLF 81_ FSDLK 86_ QFQDQ 91_ KRSQR 96_ DILDK 101_ TGDKL 106_ KFCLF 111_ TKWLK 116_ NNFEI 121_ QKSLD 126_ GFTIQ 131_ VFTKN 136_ QRISF 141_ EVLAA 146_ FNALS 151_ LNDNP 156_ SPWIY 161_ RELKR 166_ SLDKT 171_ NASPG 176_ EFAVC 181_ FTELQ 186_ QKFFD 191_ NRPGK 196_ LKDLI 201_ LLIKH 206_ WHQQC 211_ QKKIK 216_ DLPSL 221_ SPYAL 226_ ELLTV 231_ YAWEQ 236_ GCRKD 241_ NFDIA 246_ EGVRT 251_ VLELI 256_ KCQEK 261_ LCIYW 266_ MVNYN 271_ FEDET 276_ IRNIL 281_ LHQLQ 286_ SARPV 291_ ILDPV 296_ DPTNN 301_ VSGDK 306_ ICWQW 311_ LKKEA 316_ QTWLT 321_ SPNLD 326_ NELPA 331_ PSWNV 336_ LPAPL 341_ FTTPG 346_ HLLDK 351_ FIKEF 356_ LQPNK 361_ CFLEQ 366_ IDSAV 371_ NIIRT 376_ FLKEN 381_ CFRQS 386_ TAKIQ 391_ IVRGG 396_ STAKG 401_ TALKT 406_ GSDAD 411_ LVVFH 416_ NSLKS 421_ YTSQK 426_ NERHK 431_ IVKEI 436_ HEQLK 441_ AFWRE 446_ KEEEL 451_ EVSFE 456_ PPKWK 461_ APRVL 466_ SFSLK 471_ SKVLN 476_ ESVSF 481_ DVLPA 486_ FNALG 491_ QLSSG 496_ STPSP 501_ EVYAG 506_ LIDLY 511_ KSSDL 516_ PGGEF 521_ STCFT 526_ VLQRN 531_ FIRSR 536_ PTKLK 541_ DLIRL 546_ VKHWY 551_ KECER 556_ KLKPK 561_ GSLPP 566_ KYALE 571_ LLTIY 576_ AWEQG 581_ SGVPD 586_ FDTAE 591_ GFRTV 596_ LELVT 601_ QYQQL 606_ CIFWK 611_ VNYNF 616_ EDETV 621_ RKFLL 626_ SQLQK 631_ TRPVI 636_ LDPAE 641_ PTGDV 646_ GGGDR 651_ WCWHL 656_ LAKEA 661_ KEWLS 666_ SPCFK 671_ DGTGN 676_ PIPPW 681_ KVPTM 686_ QTPGS 691_ CGARI 696_ HPIVN 701_ EMFSS 706_ RSHRI 711_LNNNS
1: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:10464285, PubMed:11682059, PubMed:9880569). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:10464285, PubMed:9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity)