CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
1_MIETY 6_ NQTSP 11_ RSAAT 16_ GLPIS 21_ MKIFM 26_ YLLTV 31_ FLITQ 36_ MIGSA 41_ LFAVY 46_ LHRRL 51_ DKIED 56_ ERNLH 61_ EDFVF 66_ MKTIQ 71_ RCNTG 76_ ERSLS 81_ LLNCE 86_ EIKSQ 91_ FEGFV 96_ KDIML 101_ NKEET 106_ KKENS 111_ FEMQK 116_ GDQNP 121_ QIAAH 126_ VISEA 131_ SSKTT 136_ SVLQW 141_ AEKGY 146_ YTMSN 151_ NLVTL 156_ ENGKQ 161_ LTVKR 166_ QGLYY 171_ IYAQV 176_ TFCSN 181_ REASS 186_ QAPFI 191_ ASLCL 196_ KSPGR 201_ FERIL 206_ LRAAN 211_ THSSA 216_ KPCGQ 221_ QSIHL 226_ GGVFE 231_ LQPGA 236_ SVFVN 241_ VTDPS 246_ QVSHG 251_ TGFTS 256_FGLLK
1: Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Costimulates T-cell proliferation and cytokine production (PubMed:8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B (PubMed:15067037, PubMed:31331973). Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity)
2: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling