Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)
1_MGAQF 6_ SKTAA 11_ KGEAA 16_ AERPG 21_ EAAVA 26_ SSPSK 31_ ANGQE 36_ NGHVK 41_ VNGDA 46_ SPAAA 51_ ESGAK 56_ EELQA 61_ NGSAP 66_ AADKE 71_ EPAAA 76_ GSGAA 81_ SPSAA 86_ EKGEP 91_ AAAAA 96_ PEAGA 101_ SPVEK 106_ EAPAE 111_ GEAAE 116_ PGSPT 121_ AAEGE 126_ AASAA 131_ SSTSS 136_ PKAED 141_ GATPS 146_ PSNET 151_ PKKKK 156_ KRFSF 161_ KKSFK 166_ LSGFS 171_ FKKNK 176_ KEAGE 181_ GGEAE 186_ APAAE 191_ GGKDE 196_ AAGGA 201_ AAAAA 206_ EAGAA 211_ SGEQA 216_ AAPGE 221_ EAAAG 226_ EEGAA 231_ GGDPQ 236_ EAKPQ 241_ EAAVA 246_ PEKPP 251_ ASDET 256_ KAAEE 261_ PSKVE 266_ EKKAE 271_ EAGAS 276_ AAACE 281_ APSAA 286_ GPGAP 291_ PEQEA 296_ APAEE 301_ PAAAA 306_ ASSAC 311_ AAPSQ 316_ EAQPE 321_ CSPEA 326_PPAEA
1: Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity)