cGMP-gated cation channel alpha-1 (Cyclic nucleotide-gated cation channel 1) (Cyclic nucleotide-gated channel alpha-1) (CNG channel alpha-1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel, photoreceptor) (Rod photoreceptor cGMP-gated channel subunit alpha)
1_MKNNI 6_ INTQQ 11_ SFVTM 16_ PNVIV 21_ PDIEK 26_ EIRRM 31_ ENGAC 36_ SSFSE 41_ DDDSA 46_ STSEE 51_ SENEN 56_ PHARG 61_ SFSYK 66_ SLRKG 71_ GPSQR 76_ EQYLP 81_ GAIAL 86_ FNVNN 91_ SSNKD 96_ QEPEE 101_ KKKKK 106_ KEKKS 111_ KSDDK 116_ NENKN 121_ DPEKK 126_ KKKKD 131_ KEKKK 136_ KEEKS 141_ KDKKE 146_ EEKKE 151_ VVVID 156_ PSGNT 161_ YYNWL 166_ FCITL 171_ PVMYN 176_ WTMVI 181_ ARACF 186_ DELQS 191_ DYLEY 196_ WLILD 201_ YVSDI 206_ VYLID 211_ MFVRT 216_ RTGYL 221_ EQGLL 226_ VKEEL 231_ KLINK 236_ YKSNL 241_ QFKLD 246_ VLSLI 251_ PTDLL 256_ YFKLG 261_ WNYPE 266_ IRLNR 271_ LLRFS 276_ RMFEF 281_ FQRTE 286_ TRTNY 291_ PNIFR 296_ ISNLV 301_ MYIVI 306_ IIHWN 311_ ACVFY 316_ SISKA 321_ IGFGN 326_ DTWVY 331_ PDIND 336_ PEFGR 341_ LARKY 346_ VYSLY 351_ WSTLT 356_ LTTIG 361_ ETPPP 366_ VRDSE 371_ YVFVV 376_ VDFLI 381_ GVLIF 386_ ATIVG 391_ NIGSM 396_ ISNMN 401_ AARAE 406_ FQARI 411_ DAIKQ 416_ YMHFR 421_ NVSKD 426_ MEKRV 431_ IKWFD 436_ YLWTN 441_ KKTVD 446_ EKEVL 451_ KYLPD 456_ KLRAE 461_ IAINV 466_ HLDTL 471_ KKVRI 476_ FADCE 481_ AGLLV 486_ ELVLK 491_ LQPQV 496_ YSPGD 501_ YICKK 506_ GDIGR 511_ EMYII 516_ KEGKL 521_ AVVAD 526_ DGVTQ 531_ FVVLS 536_ DGSYF 541_ GEISI 546_ LNIKG 551_ SKAGN 556_ RRTAN 561_ IKSIG 566_ YSDLF 571_ CLSKD 576_ DLMEA 581_ LTEYP 586_ DAKTM 591_ LEEKG 596_ KQILM 601_ KDGLL 606_ DLNIA 611_ NAGSD 616_ PKDLE 621_ EKVTR 626_ MEGSV 631_ DLLQT 636_ RFARI 641_ LAEYE 646_ SMQQK 651_ LKQRL 656_ TKVEK 661_ FLKPL 666_ IDTEF 671_ SSIEG 676_ PGAES 681_GPIDS
1: Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels