Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (Guanine nucleotide-binding protein G(y) subunit alpha)
1_MTLES 6_ MMACC 11_ LSDEV 16_ KESKR 21_ INAEI 26_ EKQLR 31_ RDKRD 36_ ARREL 41_ KLLLL 46_ GTGES 51_ GKSTF 56_ IKQMR 61_ IIHGA 66_ GYSEE 71_ DKRGF 76_ TKLVY 81_ QNIFT 86_ AMQAM 91_ IRAME 96_ TLKIL 101_ YKYEQ 106_ NKANA 111_ LLIRE 116_ VDVEK 121_ VTTFE 126_ HQYVS 131_ AIKTL 136_ WEDPG 141_ IQECY 146_ DRRRE 151_ YQLSD 156_ SAKYY 161_ LTDVD 166_ RIATL 171_ GYLPT 176_ QQDVL 181_ RVRVP 186_ TTGII 191_ EYPFD 196_ LENII 201_ FRMVD 206_ VGGQR 211_ SERRK 216_ WIHCF 221_ ENVTS 226_ IMFLV 231_ ALSEY 236_ DQVLV 241_ ESDNE 246_ NRMEE 251_ SKALF 256_ RTIIT 261_ YPWFQ 266_ NSSVI 271_ LFLNK 276_ KDLLE 281_ DKILY 286_ SHLVD 291_ YFPEF 296_ DGPQR 301_ DAQAA 306_ REFIL 311_ KMFVD 316_ LNPDS 321_ DKIIY 326_ SHFTC 331_ ATDTE 336_ NIRFV 341_ FAAVK 346_ DTILQ 351_LNLKE
1: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:31073061). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:31073061). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:31073061). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:31073061). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:31073061). Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNA11 activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:31073061). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNAQ, required for heart development (By similarity). In the respiratory epithelium, transmits OXGR1-dependent signals that lead to downstream intracellular Ca(2+) release and mucocilliary clearance of airborne pathogens