Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase)
1_MLLPA 6_ PALRR 11_ ALLSR 16_ PWTGA 21_ GLRWK 26_ HTSSL 31_ KVANE 36_ PVLAF 41_ TQGSP 46_ ERDAL 51_ QKALK 56_ DLKGR 61_ MEAIP 66_ CVVGD 71_ EEVWT 76_ SDVQY 81_ QVSPF 86_ NHGHK 91_ VAKFC 96_ YADKS 101_ LLNKA 106_ IEAAL 111_ AARKE 116_ WDLKP 121_ IADRA 126_ QIFLK 131_ AADML 136_ SGPRR 141_ AEILA 146_ KTMVG 151_ QGKTV 156_ IQAEI 161_ DAAAE 166_ LIDFF 171_ RFNAK 176_ YAVEL 181_ EGQQP 186_ ISVPP 191_ STNST 196_ VYRGL 201_ EGFVA 206_ AISPF 211_ NFTAI 216_ GGNLA 221_ GAPAL 226_ MGNVV 231_ LWKPS 236_ DTAML 241_ ASYAV 246_ YRILR 251_ EAGLP 256_ PNIIQ 261_ FVPAD 266_ GPLFG 271_ DTVTS 276_ SEHLC 281_ GINFT 286_ GSVPT 291_ FKHLW 296_ KQVAQ 301_ NLDRF 306_ HTFPR 311_ LAGEC 316_ GGKNF 321_ HFVHR 326_ SADVE 331_ SVVSG 336_ TLRSA 341_ FEYGG 346_ QKCSA 351_ CSRLY 356_ VPHSL 361_ WPQIK 366_ GRLLE 371_ EHSRI 376_ KVGDP 381_ AEDFG 386_ TFFSA 391_ VIDAK 396_ SFARI 401_ KKWLE 406_ HARSS 411_ PSLTI 416_ LAGGK 421_ CDDSV 426_ GYFVE 431_ PCIVE 436_ SKDPQ 441_ EPIMK 446_ EEIFG 451_ PVLSV 456_ YVYPD 461_ DKYKE 466_ TLQLV 471_ DSTTS 476_ YGLTG 481_ AVFSQ 486_ DKDVV 491_ QEATK 496_ VLRNA 501_ AGNFY 506_ INDKS 511_ TGSIV 516_ GQQPF 521_ GGARA 526_ SGTND 531_ KPGGP 536_ HYILR 541_ WTSPQ 546_ VIKET 551_ HKPLG 556_DWSYA
1: Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes