Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3)
1_MAAAV 6_ GRLLR 11_ ASVAR 16_ HVSAI 21_ PWGIS 26_ ATAAL 31_ RPAAC 36_ GRTSL 41_ TNLLC 46_ SGSSQ 51_ AKLFS 56_ TSSSC 61_ HAPAV 66_ TQHAP 71_ YFKGT 76_ AVVNG 81_ EFKDL 86_ SLDDF 91_ KGKYL 96_ VLFFY 101_ PLDFT 106_ FVCPT 111_ EIVAF 116_ SDKAN 121_ EFHDV 126_ NCEVV 131_ AVSVD 136_ SHFSH 141_ LAWIN 146_ TPRKN 151_ GGLGH 156_ MNIAL 161_ LSDLT 166_ KQISR 171_ DYGVL 176_ LEGSG 181_ LALRG 186_ LFIID 191_ PNGVI 196_ KHLSV 201_ NDLPV 206_ GRSVE 211_ ETLRL 216_ VKAFQ 221_ YVETH 226_ GEVCP 231_ ANWTP 236_ DSPTI 241_ KPSPA 246_ ASKEY 251_FQKVN
1: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:17707404, PubMed:29438714, PubMed:33889951, PubMed:7733872). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477). Required for the maintenance of physical strength (By similarity)