Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)]
1_MPVDL 6_ SKWSG 11_ PLSLQ 16_ EVDEQ 21_ PQHPL 26_ HVTYA 31_ GAAVD 36_ ELGKV 41_ LTPTQ 46_ VKNRP 51_ TSISW 56_ DGLDS 61_ GKLYT 66_ LVLTD 71_ PDAPS 76_ RKDPK 81_ YREWH 86_ HFLVV 91_ NMKGN 96_ DISSG 101_ TVLSD 106_ YVGSG 111_ PPKGT 116_ GLHRY 121_ VWLVY 126_ EQDRP 131_ LKCDE 136_ PILSN 141_ RSGDH 146_ RGKFK 151_ VASFR 156_ KKYEL 161_ RAPVA 166_ GTCYQ 171_ AEWDD 176_ YVPKL 181_YEQLS
1: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation
2: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity)