Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60)
1_MRLRR 6_ LALFP 11_ GVALL 16_ LAAAR 21_ LAAAS 26_ DVLEL 31_ TDDNF 36_ ESRIS 41_ DTGSA 46_ GLMLV 51_ EFFAP 56_ WCGHC 61_ KRLAP 66_ EYEAA 71_ ATRLK 76_ GIVPL 81_ AKVDC 86_ TANTN 91_ TCNKY 96_ GVSGY 101_ PTLKI 106_ FRDGE 111_ EAGAY 116_ DGPRT 121_ ADGIV 126_ SHLKK 131_ QAGPA 136_ SVPLR 141_ TEEEF 146_ KKFIS 151_ DKDAS 156_ IVGFF 161_ DDSFS 166_ EAHSE 171_ FLKAA 176_ SNLRD 181_ NYRFA 186_ HTNVE 191_ SLVNE 196_ YDDNG 201_ EGIIL 206_ FRPSH 211_ LTNKF 216_ EDKTV 221_ AYTEQ 226_ KMTSG 231_ KIKKF 236_ IQENI 241_ FGICP 246_ HMTED 251_ NKDLI 256_ QGKDL 261_ LIAYY 266_ DVDYE 271_ KNAKG 276_ SNYWR 281_ NRVMM 286_ VAKKF 291_ LDAGH 296_ KLNFA 301_ VASRK 306_ TFSHE 311_ LSDFG 316_ LESTA 321_ GEIPV 326_ VAIRT 331_ AKGEK 336_ FVMQE 341_ EFSRD 346_ GKALE 351_ RFLQD 356_ YFDGN 361_ LKRYL 366_ KSEPI 371_ PESND 376_ GPVKV 381_ VVAEN 386_ FDEIV 391_ NNENK 396_ DVLIE 401_ FYAPW 406_ CGHCK 411_ NLEPK 416_ YKELG 421_ EKLSK 426_ DPNIV 431_ IAKMD 436_ ATAND 441_ VPSPY 446_ EVRGF 451_ PTIYF 456_ SPANK 461_ KLNPK 466_ KYEGG 471_ RELSD 476_ FISYL 481_ QREAT 486_ NPPVI 491_ QEEKP 496_KKKKK
1: Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323)