Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
1_MAAAD 6_ GDDSL 11_ YPIAV 16_ LIDEL 21_ RNEDV 26_ QLRLN 31_ SIKKL 36_ STIAL 41_ ALGVE 46_ RTRSE 51_ LLPFL 56_ TDTIY 61_ DEDEV 66_ LLALA 71_ EQLGT 76_ FTTLV 81_ GGPEY 86_ VHCLL 91_ PPLES 96_ LATVE 101_ ETVVR 106_ DKAVE 111_ SLRAI 116_ SHEHS 121_ PSDLE 126_ AHFVP 131_ LVKRL 136_ AGGDW 141_ FTSRT 146_ SACGL 151_ FSVCY 156_ PRVSS 161_ AVKAE 166_ LRQYF 171_ RNLCS 176_ DDTPM 181_ VRRAA 186_ ASKLG 191_ EFAKV 196_ LELDN 201_ VKSEI 206_ IPMFS 211_ NLASD 216_ EQDSV 221_ RLLAV 226_ EACVN 231_ IAQLL 236_ PQEDL 241_ EALVM 246_ PTLRQ 251_ AAEDK 256_ SWRVR 261_ YMVAD 266_ KFTEL 271_ QKAVG 276_ PEITK 281_ TDLVP 286_ AFQNL 291_ MKDCE 296_ AEVRA 301_ AASHK 306_ VKEFC 311_ ENLSA 316_ DCREN 321_ VIMSQ 326_ ILPCI 331_ KELVS 336_ DANQH 341_ VKSAL 346_ ASVIM 351_ GLSPI 356_ LGKDN 361_ TIEHL 366_ LPLFL 371_ AQLKD 376_ ECPEV 381_ RLNII 386_ SNLDC 391_ VNEVI 396_ GIRQL 401_ SQSLL 406_ PAIVE 411_ LAEDA 416_ KWRVR 421_ LAIIE 426_ YMPLL 431_ AGQLG 436_ VEFFD 441_ EKLNS 446_ LCMAW 451_ LVDHV 456_ YAIRE 461_ AATSN 466_ LKKLV 471_ EKFGK 476_ EWAHA 481_ TIIPK 486_ VLAMS 491_ GDPNY 496_ LHRMT 501_ TLFCI 506_ NVLSE 511_ VCGQD 516_ ITTKH 521_ MLPTV 526_ LRMAG 531_ DPVAN 536_ VRFNV 541_ AKSLQ 546_ KIGPI 551_ LDNST 556_ LQSEV 561_ KPILE 566_ KLTQD 571_ QDVDV 576_ KYFAQ 581_EALTV
1: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:15525651, PubMed:16580887, PubMed:33243860, PubMed:33633399, PubMed:34004147, PubMed:8694763). Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:18782753, PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753, PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, acts as a scaffolding subunit for PPP2CA, which catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702)