T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6]
1_MWLFF 6_ GITGL 11_ LTAAL 16_ SGHPS 21_ PAPPD 26_ QLNTS 31_ SAESE 36_ LWEPG 41_ ERLPV 46_ RLTNG 51_ SSSCS 56_ GTVEV 61_ RLEAS 66_ WEPAC 71_ GALWD 76_ SRAAE 81_ AVCRA 86_ LGCGG 91_ AEAAS 96_ QLAPP 101_ TPELP 106_ PPPAA 111_ GNTSV 116_ AANAT 121_ LAGAP 126_ ALLCS 131_ GAEWR 136_ LCEVV 141_ EHACR 146_ SDGRR 151_ ARVTC 156_ AENRA 161_ LRLVD 166_ GGGAC 171_ AGRVE 176_ MLEHG 181_ EWGSV 186_ CDDTW 191_ DLEDA 196_ HVVCR 201_ QLGCG 206_ WAVQA 211_ LPGLH 216_ FTPGR 221_ GPIHR 226_ DQVNC 231_ SGAEA 236_ YLWDC 241_ PGLPG 246_ QHYCG 251_ HKEDA 256_ GAVCS 261_ EHQSW 266_ RLTGG 271_ ADRCE 276_ GQVEV 281_ HFRGV 286_ WNTVC 291_ DSEWY 296_ PSEAK 301_ VLCQS 306_ LGCGT 311_ AVERP 316_ KGLPH 321_ SLSGR 326_ MYYSC 331_ NGEEL 336_ TLSNC 341_ SWRFN 346_ NSNLC 351_ SQSLA 356_ ARVLC 361_ SASRS 366_ LHNLS 371_ TPEVP 376_ ASVQT 381_ VTIES 386_ SVTVK 391_ IENKE 396_ SRELM 401_ LLIPS 406_ IVLGI 411_ LLLGS 416_ LIFIA 421_ FILLR 426_ IKGKY 431_ ALPVM 436_ VNHQH 441_ LPTTI 446_ PAGSN 451_ SYQPV 456_ PITIP 461_ KEVFM 466_ LPIQV 471_ QAPPP 476_ EDSDS 481_ GSDSD 486_ YEHYD 491_ FSAQP 496_ PVALT 501_ TFYNS 506_ QRHRV 511_ TDEEV 516_ QQSRF 521_ QMPPL 526_ EEGLE 531_ ELHAS 536_ HIPTA 541_ NPGHC 546_ ITDPP 551_ SLGPQ 556_ YHPRS 561_ NSESS 566_ TSSGE 571_ DYCNS 576_ PKSKL 581_ PPWNP 586_ QVFSS 591_ ERSSF 596_ LEQPP 601_ NLELA 606_ GTQPA 611_ FSAGP 616_ PADDS 621_ SSTSS 626_ GEWYQ 631_ NFQPP 636_ PQPPS 641_ EEQFG 646_ CPGSP 651_ SPQPD 656_ STDND 661_DYDDI
1: Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24584089, PubMed:24945728). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as a costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777)