G1/S-specific cyclin-D2
1_MELLC 6_ HEVDP 11_ VRRAV 16_ RDRNL 21_ LRDDR 26_ VLQNL 31_ LTIEE 36_ RYLPQ 41_ CSYFK 46_ CVQKD 51_ IQPYM 56_ RRMVA 61_ TWMLE 66_ VCEEQ 71_ KCEEE 76_ VFPLA 81_ MNYLD 86_ RFLAG 91_ VPTPK 96_ SHLQL 101_ LGAVC 106_ MFLAS 111_ KLKET 116_ SPLTA 121_ EKLCI 126_ YTDNS 131_ IKPQE 136_ LLEWE 141_ LVVLG 146_ KLKWN 151_ LAAVT 156_ PHDFI 161_ EHILR 166_ KLPQQ 171_ REKLS 176_ LIRKH 181_ AQTFI 186_ ALCAT 191_ DFKFA 196_ MYPPS 201_ MIATG 206_ SVGAA 211_ ICGLQ 216_ QDEEV 221_ SSLTC 226_ DALTE 231_ LLAKI 236_ TNTDV 241_ DCLKA 246_ CQEQI 251_ EAVLL 256_ NSLQQ 261_ YRQDQ 266_ RDGSK 271_ SEDEL 276_ DQAST 281_PTDVR
1: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:18827403, PubMed:8114739). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:18827403, PubMed:8114739). Hypophosphorylates RB1 in early G(1) phase (PubMed:18827403, PubMed:8114739). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:18827403, PubMed:8114739)