Lens fiber major intrinsic protein (Aquaporin-0) (MIP26) (MP26)
1_MWELR 6_ SASFW 11_ RAIFA 16_ EFFAT 21_ LFYVF 26_ FGLGS 31_ SLRWA 36_ PGPLH 41_ VLQVA 46_ MAFGL 51_ ALATL 56_ VQSVG 61_ HISGA 66_ HVNPA 71_ VTFAF 76_ LVGSQ 81_ MSLLR 86_ AFCYM 91_ AAQLL 96_ GAVAG 101_ AAVLY 106_ SVTPP 111_ AVRGN 116_ LALNT 121_ LHPAV 126_ SVGQA 131_ TTVEI 136_ FLTLQ 141_ FVLCI 146_ FATYD 151_ ERRNG 156_ QLGSV 161_ ALAVG 166_ FSLAL 171_ GHLFG 176_ MYYTG 181_ AGMNP 186_ ARSFA 191_ PAILT 196_ GNFTN 201_ HWVYW 206_ VGPII 211_ GGGLG 216_ SLLYD 221_ FLLFP 226_ RLKSI 231_ SERLS 236_ VLKGA 241_ KPDVS 246_ NGQPE 251_ VTGEP 256_VELNT
1: Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:11001937, PubMed:24120416). Specifically expressed in lens fiber cells, this aquaporin is crucial for maintaining lens water homeostasis and transparency. Beyond water permeability, it also acts as a cell-to-cell adhesion molecule, forming thin junctions between lens fiber cells that are essential for maintaining the ordered structure and transparency of the lens (PubMed:24120416)