M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A)
1_MELGP 6_ EPPHR 11_ RRLLF 16_ ACSPP 21_ PASQP 26_ VVKAL 31_ FGASA 36_ AGGLS 41_ PVTNL 46_ TVTMD 51_ QLQGL 56_ GSDYE 61_ QPLEV 66_ KNNSN 71_ LQRMG 76_ SSEST 81_ DSGFC 86_ LDSPG 91_ PLDSK 96_ ENLEN 101_ PMRRI 106_ HSLPQ 111_ KLLGC 116_ SPALK 121_ RSHSD 126_ SLDHD 131_ IFQLI 136_ DPDEN 141_ KENEA 146_ FEFKK 151_ PVRPV 156_ SRGCL 161_ HSHGL 166_ QEGKD 171_ LFTQR 176_ QNSAP 181_ ARMLS 186_ SNERD 191_ SSEPG 196_ NFIPL 201_ FTPQS 206_ PVTAT 211_ LSDED 216_ DGFVD 221_ LLDGE 226_ NLKNE 231_ EETPS 236_ CMASL 241_ WTAPL 246_ VMRTT 251_ NLDNR 256_ CKLFD 261_ SPSLC 266_ SSSTR 271_ SVLKR 276_ PERSQ 281_ EESPP 286_ GSTKR 291_ RKSMS 296_ GASPK 301_ ESTNP 306_ EKAHE 311_ TLHQS 316_ LSLAS 321_ SPKGT 326_ IENIL 331_ DNDPR 336_ DLIGD 341_ FSKGY 346_ LFHTV 351_ AGKHQ 356_ DLKYI 361_ SPEIM 366_ ASVLN 371_ GKFAN 376_ LIKEF 381_ VIIDC 386_ RYPYE 391_ YEGGH 396_ IKGAV 401_ NLHME 406_ EEVED 411_ FLLKK 416_ PIVPT 421_ DGKRV 426_ IVVFH 431_ CEFSS 436_ ERGPR 441_ MCRYV 446_ RERDR 451_ LGNEY 456_ PKLHY 461_ PELYV 466_ LKGGY 471_ KEFFM 476_ KCQSY 481_ CEPPS 486_ YRPMH 491_ HEDFK 496_ EDLKK 501_ FRTKS 506_ RTWAG 511_ EKSKR 516_EMYSR
1: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007)